Synthesis of Steroidal Aziridines

R. Ikan; A. Mabktts; Z. Goldschmidt

doi:10.1021/jo00977a009

Synthesis of Steroidal Aziridines

R. Ikan, A. Mabktts, Z. Goldschmidt

Research output: Contribution to journal › Article › peer-review

Abstract

Desmostanyl 3a-acetate (5) was synthesized from litocholic acid and converted into the aziridine 8, the essential steps being addition of iodine isocyanate to 5 which was converted to the corresponding carbamate 7. Treatment of 7 With alcoholic base formed the aziridine 8. Analogous sequence of reactions led to the formation of aziridine 9 from stigmasteryl acetate.

Original language	English
Pages (from-to)	1892-1894
Number of pages	3
Journal	Journal of Organic Chemistry
Volume	37
Issue number	12
DOIs	https://doi.org/10.1021/jo00977a009
State	Published - 1 Jun 1972
Externally published	Yes

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title = "Synthesis of Steroidal Aziridines",

abstract = "Desmostanyl 3a-acetate (5) was synthesized from litocholic acid and converted into the aziridine 8, the essential steps being addition of iodine isocyanate to 5 which was converted to the corresponding carbamate 7. Treatment of 7 With alcoholic base formed the aziridine 8. Analogous sequence of reactions led to the formation of aziridine 9 from stigmasteryl acetate.",

author = "R. Ikan and A. Mabktts and Z. Goldschmidt",

year = "1972",

month = jun,

day = "1",

doi = "10.1021/jo00977a009",

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N2 - Desmostanyl 3a-acetate (5) was synthesized from litocholic acid and converted into the aziridine 8, the essential steps being addition of iodine isocyanate to 5 which was converted to the corresponding carbamate 7. Treatment of 7 With alcoholic base formed the aziridine 8. Analogous sequence of reactions led to the formation of aziridine 9 from stigmasteryl acetate.

AB - Desmostanyl 3a-acetate (5) was synthesized from litocholic acid and converted into the aziridine 8, the essential steps being addition of iodine isocyanate to 5 which was converted to the corresponding carbamate 7. Treatment of 7 With alcoholic base formed the aziridine 8. Analogous sequence of reactions led to the formation of aziridine 9 from stigmasteryl acetate.

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Synthesis of Steroidal Aziridines

Abstract

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