Synthesis of N‐[N‐L‐γ‐glutamyl‐L‐cysteinyl‐(carbonyl‐14C)]‐glycine (glutathione‐14C) and of [Cys‐14CO]‐(5S,6R)‐LTC4

P. Parent, F. Leborgne, J. P. Lellouche, J. P. Beaucourt, A. Vanhove

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[Cys‐14CO]‐glutathione or N‐[N‐L‐γ‐glutamyl‐L‐cysteinyl‐14CO] glycine was prepared by chemical synthesis, with the L,L‐natural configuration and a radiochemical yield of 1% based on sodium [14C] cyanide. This labelled compound was used to obtain [Cys‐14CO] with a yield of 15%. [Cys‐14CO]‐glutathione and [Cys‐14CO]LTC4 had a specific activity of 50 mCi/mmol (1.85 GBq/mmol).

Original languageEnglish
Pages (from-to)633-644
Number of pages12
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Issue number6
StatePublished - Jun 1990
Externally publishedYes


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