Synthesis of leukotrienes labelled with deuterium: [11,12,14,15‐2H4]‐LTA4 ‐LTC4, ‐LTD4 and ‐LTE4

J. P. Lellouche; F. Aubert; J. P. Noel; C. Boullais; J. P. Beaucourt

doi:10.1002/jlcr.2580270415

Synthesis of leukotrienes labelled with deuterium: [11,12,14,15‐²H₄]‐LTA₄ ‐LTC₄, ‐LTD₄ and ‐LTE₄

J. P. Lellouche, F. Aubert, J. P. Noel, C. Boullais, J. P. Beaucourt

Serv. des Molecules Marquees

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Semi‐hydrogenation by D₂ gas on Lindlar catalyst of an acetylenic precursor led to [11,12,14,15‐²H₄]‐LTA₄ methyl ester 1a. Nucleophilic opening of the epoxide ring by amino thioacids afforded after saponification the corresponding deuterated peptidoleukotrienes LTC₄, LTD₄ and LTE₄.

Original language	English
Pages (from-to)	473-480
Number of pages	8
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	27
Issue number	4
DOIs	https://doi.org/10.1002/jlcr.2580270415
State	Published - Apr 1989
Externally published	Yes

Keywords

Semi‐hydrogenation
deuterated leukotrienes
deuterium
peptidoleukotrienes

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10.1002/jlcr.2580270415

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title = "Synthesis of leukotrienes labelled with deuterium: [11,12,14,15‐2H4]‐LTA4 ‐LTC4, ‐LTD4 and ‐LTE4",

abstract = "Semi‐hydrogenation by D2 gas on Lindlar catalyst of an acetylenic precursor led to [11,12,14,15‐2H4]‐LTA4 methyl ester 1a. Nucleophilic opening of the epoxide ring by amino thioacids afforded after saponification the corresponding deuterated peptidoleukotrienes LTC4, LTD4 and LTE4.",

keywords = "Semi‐hydrogenation, deuterated leukotrienes, deuterium, peptidoleukotrienes",

author = "Lellouche, {J. P.} and F. Aubert and Noel, {J. P.} and C. Boullais and Beaucourt, {J. P.}",

year = "1989",

month = apr,

doi = "10.1002/jlcr.2580270415",

language = "אנגלית",

volume = "27",

pages = "473--480",

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T1 - Synthesis of leukotrienes labelled with deuterium

T2 - [11,12,14,15‐2H4]‐LTA4 ‐LTC4, ‐LTD4 and ‐LTE4

AU - Lellouche, J. P.

AU - Aubert, F.

AU - Noel, J. P.

AU - Boullais, C.

AU - Beaucourt, J. P.

PY - 1989/4

Y1 - 1989/4

N2 - Semi‐hydrogenation by D2 gas on Lindlar catalyst of an acetylenic precursor led to [11,12,14,15‐2H4]‐LTA4 methyl ester 1a. Nucleophilic opening of the epoxide ring by amino thioacids afforded after saponification the corresponding deuterated peptidoleukotrienes LTC4, LTD4 and LTE4.

AB - Semi‐hydrogenation by D2 gas on Lindlar catalyst of an acetylenic precursor led to [11,12,14,15‐2H4]‐LTA4 methyl ester 1a. Nucleophilic opening of the epoxide ring by amino thioacids afforded after saponification the corresponding deuterated peptidoleukotrienes LTC4, LTD4 and LTE4.

KW - Semi‐hydrogenation

KW - deuterated leukotrienes

KW - deuterium

KW - peptidoleukotrienes

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SN - 0362-4803

VL - 27

SP - 473

EP - 480

JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

IS - 4

ER -

Synthesis of leukotrienes labelled with deuterium: [11,12,14,15‐²H₄]‐LTA₄ ‐LTC₄, ‐LTD₄ and ‐LTE₄

Abstract

Keywords

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