Synthesis of indazole motifs and their medicinal importance: An overview

Digambar D. Gaikwad; Archana D. Chapolikar; Chandrashekhar G. Devkate; Khandu D. Warad; Amit P. Tayade; Rajendra P. Pawar; Abraham J. Domb

doi:10.1016/j.ejmech.2014.11.029

Synthesis of indazole motifs and their medicinal importance: An overview

Digambar D. Gaikwad
, Archana D. Chapolikar
, Chandrashekhar G. Devkate
, Khandu D. Warad
, Amit P. Tayade
, Rajendra P. Pawar
, Abraham J. Domb

Research output: Contribution to journal › Short survey › peer-review

311 Scopus citations

Abstract

Indazoles is an important class of heterocyclic compounds having a wide range of biological and pharmaceutical applications. There is enormous potential in the synthesis of novel heterocyclic systems to be used as building blocks for the next generation of pharmaceuticals as anti-bacterial, anti-depressant and anti-inflammatory. Fused aromatic 1H and 2H-indazoles are well recognized for anti-hypertensive and anti-cancer properties. The present review focuses on novel routes of their synthesis and various biological activities.

Original language	English
Pages (from-to)	707-731
Number of pages	25
Journal	European Journal of Medicinal Chemistry
Volume	90
DOIs	https://doi.org/10.1016/j.ejmech.2014.11.029
State	Published - 27 Jan 2015
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2014 Elsevier Masson SAS.

Funding

The author is thankful for the financial support from the University Grant Commission (UGC) (File No. 47-301/12 (WRO), Date: – 26 Feb. 2013) , under ‘Western Regional Office”, Pune (WRO).

Funders	Funder number
University Grants Commission	47-301/12

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Antipsychotic
Antiretroviral
Antitumor
Axitinib
Chronic pain
Narcotic

Access to Document

10.1016/j.ejmech.2014.11.029

Cite this

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title = "Synthesis of indazole motifs and their medicinal importance: An overview",

abstract = "Indazoles is an important class of heterocyclic compounds having a wide range of biological and pharmaceutical applications. There is enormous potential in the synthesis of novel heterocyclic systems to be used as building blocks for the next generation of pharmaceuticals as anti-bacterial, anti-depressant and anti-inflammatory. Fused aromatic 1H and 2H-indazoles are well recognized for anti-hypertensive and anti-cancer properties. The present review focuses on novel routes of their synthesis and various biological activities.",

keywords = "Antipsychotic, Antiretroviral, Antitumor, Axitinib, Chronic pain, Narcotic",

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note = "Publisher Copyright: {\textcopyright} 2014 Elsevier Masson SAS.",

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doi = "10.1016/j.ejmech.2014.11.029",

language = "אנגלית",

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T2 - An overview

AU - Gaikwad, Digambar D.

AU - Chapolikar, Archana D.

AU - Devkate, Chandrashekhar G.

AU - Warad, Khandu D.

AU - Tayade, Amit P.

AU - Pawar, Rajendra P.

AU - Domb, Abraham J.

PY - 2015/1/27

Y1 - 2015/1/27

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AB - Indazoles is an important class of heterocyclic compounds having a wide range of biological and pharmaceutical applications. There is enormous potential in the synthesis of novel heterocyclic systems to be used as building blocks for the next generation of pharmaceuticals as anti-bacterial, anti-depressant and anti-inflammatory. Fused aromatic 1H and 2H-indazoles are well recognized for anti-hypertensive and anti-cancer properties. The present review focuses on novel routes of their synthesis and various biological activities.

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KW - Antiretroviral

KW - Antitumor

KW - Axitinib

KW - Chronic pain

KW - Narcotic

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ER -

Synthesis of indazole motifs and their medicinal importance: An overview

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

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