Synthesis of indazole motifs and their medicinal importance: An overview

Digambar D. Gaikwad, Archana D. Chapolikar, Chandrashekhar G. Devkate, Khandu D. Warad, Amit P. Tayade, Rajendra P. Pawar, Abraham J. Domb

Research output: Contribution to journalShort surveypeer-review

260 Scopus citations

Abstract

Indazoles is an important class of heterocyclic compounds having a wide range of biological and pharmaceutical applications. There is enormous potential in the synthesis of novel heterocyclic systems to be used as building blocks for the next generation of pharmaceuticals as anti-bacterial, anti-depressant and anti-inflammatory. Fused aromatic 1H and 2H-indazoles are well recognized for anti-hypertensive and anti-cancer properties. The present review focuses on novel routes of their synthesis and various biological activities.

Original languageEnglish
Pages (from-to)707-731
Number of pages25
JournalEuropean Journal of Medicinal Chemistry
Volume90
DOIs
StatePublished - 27 Jan 2015
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2014 Elsevier Masson SAS.

Funding

The author is thankful for the financial support from the University Grant Commission (UGC) (File No. 47-301/12 (WRO), Date: – 26 Feb. 2013) , under ‘Western Regional Office”, Pune (WRO).

FundersFunder number
University Grants Commission47-301/12

    Keywords

    • Antipsychotic
    • Antiretroviral
    • Antitumor
    • Axitinib
    • Chronic pain
    • Narcotic

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