Synthesis of heterocycles via cycloadditions to 1-azirines

David J. Anderson, Alfred Hassner

Research output: Contribution to journalReview articlepeer-review

80 Scopus citations


The wide applicability of 1-azirines as reagents for the syntheses of many well-known and novel heterocyclic systems is discussed in this article. Although most work has been concentrated on thermal and photochemical cycloaddition reactions of 1-azirines, reactions which proceed via C-N-, N=C-, or C-C-bond cleavage are included. Also, reactions which proceed formally via cycloaddition but give rise to open-chain products are also described. 1. Carbenoid Additions 2. 1, 3-Dipolar Reactions 3. Diels-Alder Reactions 4. Ketenes and Ketenimine Additions 5. Isocyanate Additions 6. Miscellaneous Additions 7. Photochemical Cycloadditions.

Original languageEnglish
Pages (from-to)483-495
Number of pages13
JournalSynthesis (Germany)
Issue number8
StatePublished - Aug 1975
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 1975 Georg Thieme Verlag. All rights reserved.


Dive into the research topics of 'Synthesis of heterocycles via cycloadditions to 1-azirines'. Together they form a unique fingerprint.

Cite this