Synthesis of glycopeptides from glucosaminic acid

Ester Abtew, Abraham J. Domb, Arijit Basu

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


We report on the synthesis of polypeptides with saccharide side chains starting from d-glucosaminic acid. The hydroxyl groups were first protected by benzylation, followed by N-carboxyanhydride formation, which was polymerized by ring opening to form a high molecular weight polyamide. De-protection of the benzyl groups yields a polypeptide with fully de-protected saccharide side chains. The resulting new non-ionic, water soluble, and optically active polymers possessing the properties of both peptides and saccharides have potential use as scaffolds for tissue engineering and drug carriers. The method described here may be extended to any saccharide α-amino acid.

Original languageEnglish
Pages (from-to)2657-2662
Number of pages6
JournalJournal of Polymer Science, Part A: Polymer Chemistry
Issue number16
StatePublished - 15 Aug 2017
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2017 Wiley Periodicals, Inc.


  • N-carboxyanhydride
  • glucosaminic acid
  • glycoamino acids
  • glycopeptides


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