TY - JOUR
T1 - Synthesis of Doped/Hybrid Carbon Dots and Their Biomedical Application
AU - Kumar, Vijay Bhooshan
AU - Porat, Ze’Ev
AU - Gedanken, Aharon
N1 - Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/3/8
Y1 - 2022/3/8
N2 - Carbon dots (CDs) are a novel type of carbon-based nanomaterial that has gained consid-erable attention for their unique optical properties, including tunable fluorescence, stability against photobleaching and photoblinking, and strong fluorescence, which is attributed to a large number of organic functional groups (amino groups, hydroxyl, ketonic, ester, and carboxyl groups, etc.). In addition, they also demonstrate high stability and electron mobility. This article reviews the topic of doped CDs with organic and inorganic atoms and molecules. Such doping leads to their func-tionalization to obtain desired physical and chemical properties for biomedical applications. We have mainly highlighted modification techniques, including doping, polymer capping, surface func-tionalization, nanocomposite and core-shell structures, which are aimed at their applications to the biomedical field, such as bioimaging, bio-sensor applications, neuron tissue engineering, drug delivery and cancer therapy. Finally, we discuss the key challenges to be addressed, the future direc-tions of research, and the possibilities of a complete hybrid format of CD-based materials.
AB - Carbon dots (CDs) are a novel type of carbon-based nanomaterial that has gained consid-erable attention for their unique optical properties, including tunable fluorescence, stability against photobleaching and photoblinking, and strong fluorescence, which is attributed to a large number of organic functional groups (amino groups, hydroxyl, ketonic, ester, and carboxyl groups, etc.). In addition, they also demonstrate high stability and electron mobility. This article reviews the topic of doped CDs with organic and inorganic atoms and molecules. Such doping leads to their func-tionalization to obtain desired physical and chemical properties for biomedical applications. We have mainly highlighted modification techniques, including doping, polymer capping, surface func-tionalization, nanocomposite and core-shell structures, which are aimed at their applications to the biomedical field, such as bioimaging, bio-sensor applications, neuron tissue engineering, drug delivery and cancer therapy. Finally, we discuss the key challenges to be addressed, the future direc-tions of research, and the possibilities of a complete hybrid format of CD-based materials.
KW - Bioimaging
KW - Biomedical
KW - CDs
KW - Characterization
KW - Doped CDs
KW - Drug delivery
KW - Hybrid CDs
KW - Neuron tissue engineering
KW - Synthesis
UR - http://www.scopus.com/inward/record.url?scp=85126025860&partnerID=8YFLogxK
U2 - 10.3390/nano12060898
DO - 10.3390/nano12060898
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C2 - 35335711
AN - SCOPUS:85126025860
SN - 2079-4991
VL - 12
JO - Nanomaterials
JF - Nanomaterials
IS - 6
M1 - 898
ER -