Synthesis of diacetylenic analogues of leukotriene A4 (LTA4) methyl ester

J. P. Lellouche; J. Deschamps; C. Boullais; J. P. Beaucourt

doi:10.1016/0040-4039(88)85088-3

Synthesis of diacetylenic analogues of leukotriene A₄ (LTA₄) methyl ester

J. P. Lellouche
, J. Deschamps
, C. Boullais
, J. P. Beaucourt

Serv. des Molecules Marquees

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Methyl (5S,6S)-epoxy-11,14-eicosadiyne-7E,9E-dienoate 1 and its 7Z isomer 2 were prepared using Wittig methodology. 1 did not inhibit human neutrophil 5-lipoxygenase but rather stimulated LTB₄ formation.

Original language	English
Pages (from-to)	3073-3076
Number of pages	4
Journal	Tetrahedron Letters
Volume	29
Issue number	25
DOIs	https://doi.org/10.1016/0040-4039(88)85088-3
State	Published - 1988
Externally published	Yes

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title = "Synthesis of diacetylenic analogues of leukotriene A4 (LTA4) methyl ester",

abstract = "Methyl (5S,6S)-epoxy-11,14-eicosadiyne-7E,9E-dienoate 1 and its 7Z isomer 2 were prepared using Wittig methodology. 1 did not inhibit human neutrophil 5-lipoxygenase but rather stimulated LTB4 formation.",

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year = "1988",

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T1 - Synthesis of diacetylenic analogues of leukotriene A4 (LTA4) methyl ester

AU - Lellouche, J. P.

AU - Deschamps, J.

AU - Boullais, C.

AU - Beaucourt, J. P.

PY - 1988

Y1 - 1988

N2 - Methyl (5S,6S)-epoxy-11,14-eicosadiyne-7E,9E-dienoate 1 and its 7Z isomer 2 were prepared using Wittig methodology. 1 did not inhibit human neutrophil 5-lipoxygenase but rather stimulated LTB4 formation.

AB - Methyl (5S,6S)-epoxy-11,14-eicosadiyne-7E,9E-dienoate 1 and its 7Z isomer 2 were prepared using Wittig methodology. 1 did not inhibit human neutrophil 5-lipoxygenase but rather stimulated LTB4 formation.

UR - https://www.scopus.com/pages/publications/0023941252

U2 - 10.1016/0040-4039(88)85088-3

DO - 10.1016/0040-4039(88)85088-3

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AN - SCOPUS:0023941252

SN - 0040-4039

VL - 29

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EP - 3076

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 25

ER -

Synthesis of diacetylenic analogues of leukotriene A₄ (LTA₄) methyl ester

Abstract

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