Synthesis of diacetylenic analogues of leukotriene A4 (LTA4) methyl ester

J. P. Lellouche, J. Deschamps, C. Boullais, J. P. Beaucourt

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Methyl (5S,6S)-epoxy-11,14-eicosadiyne-7E,9E-dienoate 1 and its 7Z isomer 2 were prepared using Wittig methodology. 1 did not inhibit human neutrophil 5-lipoxygenase but rather stimulated LTB4 formation.

Original languageEnglish
Pages (from-to)3073-3076
Number of pages4
JournalTetrahedron Letters
Volume29
Issue number25
DOIs
StatePublished - 1988
Externally publishedYes

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