TY - JOUR
T1 - Synthesis of antifungal imines as inhibitors of ergosterol biosynthesis
AU - Karan, Joydeep
AU - Kundu, Aditi
AU - Gogoi, Robin
AU - Manjaiah, Kanchikeri Math
AU - Singh, Ashutosh Kumar
AU - Mondal, Koyel
AU - Kumar, Rajesh
AU - Kaushik, Parshant
AU - Saini, Priya
AU - Rana, Virendra Singh
AU - Shakil, Najam Akhtar
N1 - Publisher Copyright:
© 2025 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
PY - 2025
Y1 - 2025
N2 - Ensuring a safe and secure supply of nutritious food for the ever growing global population necessitates the development of new eco-friendly fungicides to increase global food output by minimizing plant disease losses. Because of their broad biological relevance, imines are a promising target for fungicide development. To optimize the structure of imine derivatives for improved antifungal activity, twenty-seven Schiff bases derived from halogen-substituted benzenamines were prepared and characterized using spectral analysis in the present study. These compounds were investigated further for their in-vitro antifungal bio-efficacy against Rhizoctonia solani and Macrophomina phaseolina. Most of the compounds were effective against the test fungi with EC50 values ranging from 0.99 to 190.51 μg/mL. The substitution of chlorine at the phenyl ring attached to the carbon of the imine group resulted in the highest antifungal activity against both test fungi. The most effective antifungal compounds displayed >80% inhibition of the lanosterol-14α-demethylase enzyme.
AB - Ensuring a safe and secure supply of nutritious food for the ever growing global population necessitates the development of new eco-friendly fungicides to increase global food output by minimizing plant disease losses. Because of their broad biological relevance, imines are a promising target for fungicide development. To optimize the structure of imine derivatives for improved antifungal activity, twenty-seven Schiff bases derived from halogen-substituted benzenamines were prepared and characterized using spectral analysis in the present study. These compounds were investigated further for their in-vitro antifungal bio-efficacy against Rhizoctonia solani and Macrophomina phaseolina. Most of the compounds were effective against the test fungi with EC50 values ranging from 0.99 to 190.51 μg/mL. The substitution of chlorine at the phenyl ring attached to the carbon of the imine group resulted in the highest antifungal activity against both test fungi. The most effective antifungal compounds displayed >80% inhibition of the lanosterol-14α-demethylase enzyme.
KW - EC
KW - fungicide
KW - Imines
KW - Macrophomina phaseolina
KW - Rhizoctonia solani
UR - http://www.scopus.com/inward/record.url?scp=85215110244&partnerID=8YFLogxK
U2 - 10.1080/16583655.2024.2448897
DO - 10.1080/16583655.2024.2448897
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AN - SCOPUS:85215110244
SN - 1658-3655
VL - 19
JO - Journal of Taibah University for Science
JF - Journal of Taibah University for Science
IS - 1
M1 - 2448897
ER -