Synthesis, molecular docking, cytotoxicity and antioxidant activity evaluation of isoindoline-1,3-dione derivatives

Palanichamy Santhosh Kumar; Kuruba Bharath Kumar; Asir Obadiah; Suluvoy Jagadish Kumar; Raman Mohanapriya; Arulappan Durairaj; Subramanian Ramanathan; Samuel Vasanthkumar

doi:10.14233/ajchem.2019.22185

Synthesis, molecular docking, cytotoxicity and antioxidant activity evaluation of isoindoline-1,3-dione derivatives

Palanichamy Santhosh Kumar, Kuruba Bharath Kumar, Asir Obadiah, Suluvoy Jagadish Kumar, Raman Mohanapriya, Arulappan Durairaj, Subramanian Ramanathan, Samuel Vasanthkumar

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

A variety of amines have been employed to functionalize isobenzofuran-1,3-dione to obtain isoindoline-1,3-dione derivatives in the base free conditions. All the synthesized compounds are screened for their bioactivity through molecular docking, cytotoxicity (against HeLa) and antioxidant activity. ABTS and DPPH are employed to assess the antioxidant activity. Among the synthesized isoindoline-1,3-dione derivatives (3a-k), compound 3e has showed the best antioxidant activity and also exhibited better binding energy when docked with caspase-3 protein. Cytotoxicity of the synthesized compounds was studied against cervical cancer cell line (HeLa) and compound 3e has displayed better activity than other isoindoline derivatives.

Original language	English
Pages (from-to)	2548-2556
Number of pages	9
Journal	Asian Journal of Chemistry
Volume	31
Issue number	11
DOIs	https://doi.org/10.14233/ajchem.2019.22185
State	Published - 2019
Externally published	Yes

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© 2019 Chemical Publishing Co.. All rights reserved.

Keywords

3-dione
3-dione
Antioxidant activity
Cytotoxicity
HeLa cell lines
Isobenzofuran-1
Isoindoline-1
Molecular docking

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10.14233/ajchem.2019.22185

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abstract = "A variety of amines have been employed to functionalize isobenzofuran-1,3-dione to obtain isoindoline-1,3-dione derivatives in the base free conditions. All the synthesized compounds are screened for their bioactivity through molecular docking, cytotoxicity (against HeLa) and antioxidant activity. ABTS and DPPH are employed to assess the antioxidant activity. Among the synthesized isoindoline-1,3-dione derivatives (3a-k), compound 3e has showed the best antioxidant activity and also exhibited better binding energy when docked with caspase-3 protein. Cytotoxicity of the synthesized compounds was studied against cervical cancer cell line (HeLa) and compound 3e has displayed better activity than other isoindoline derivatives.",

keywords = "3-dione, 3-dione, Antioxidant activity, Cytotoxicity, HeLa cell lines, Isobenzofuran-1, Isoindoline-1, Molecular docking",

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AU - Kumar, Palanichamy Santhosh

AU - Kumar, Kuruba Bharath

AU - Obadiah, Asir

AU - Kumar, Suluvoy Jagadish

AU - Mohanapriya, Raman

AU - Durairaj, Arulappan

AU - Ramanathan, Subramanian

AU - Vasanthkumar, Samuel

PY - 2019

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AB - A variety of amines have been employed to functionalize isobenzofuran-1,3-dione to obtain isoindoline-1,3-dione derivatives in the base free conditions. All the synthesized compounds are screened for their bioactivity through molecular docking, cytotoxicity (against HeLa) and antioxidant activity. ABTS and DPPH are employed to assess the antioxidant activity. Among the synthesized isoindoline-1,3-dione derivatives (3a-k), compound 3e has showed the best antioxidant activity and also exhibited better binding energy when docked with caspase-3 protein. Cytotoxicity of the synthesized compounds was studied against cervical cancer cell line (HeLa) and compound 3e has displayed better activity than other isoindoline derivatives.

KW - 3-dione

KW - Antioxidant activity

KW - Cytotoxicity

KW - HeLa cell lines

KW - Isobenzofuran-1

KW - Isoindoline-1

KW - Molecular docking

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VL - 31

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JO - Asian Journal of Chemistry

JF - Asian Journal of Chemistry

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Synthesis, molecular docking, cytotoxicity and antioxidant activity evaluation of isoindoline-1,3-dione derivatives

Abstract

Bibliographical note

Keywords

UN SDGs

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