Synthesis, cytotoxic activity and molecular docking study of Bis-Rhodanine derivative

P. K. Harshitharaj, R. Kumar, S. Ravi

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


A bis-rhodanine was prepared from 1, 2 diaminopropane by microwave assisted synthesis and characterized by spectral data. The cytotoxic activity of the compound was studied by MTT assay. It showed a dose dependent cytotoxic activity and exhibited an IC50 value of 34.5 μg/ml against the HeLa cell lines. Molecular docking was carried out against the protein HPV 16 E2 present in HeLa cell line to study the binding capacity of the bis-rhodanine with the protein. It showed a docking score of -4.5 Kcal/mol involving hydrogen bonds and hydrophobic interactions.

Original languageEnglish
Pages (from-to)2478-2482
Number of pages5
JournalJournal of Chemical and Pharmaceutical Sciences
Issue number4
StatePublished - 2016
Externally publishedYes


  • 1 2 diaminopropane
  • Bis-rhodanine
  • HPV 16 E2 protein
  • Hela cell line
  • MTT assay
  • Molecular docking


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