Abstract
A bis-rhodanine was prepared from 1, 2 diaminopropane by microwave assisted synthesis and characterized by spectral data. The cytotoxic activity of the compound was studied by MTT assay. It showed a dose dependent cytotoxic activity and exhibited an IC50 value of 34.5 μg/ml against the HeLa cell lines. Molecular docking was carried out against the protein HPV 16 E2 present in HeLa cell line to study the binding capacity of the bis-rhodanine with the protein. It showed a docking score of -4.5 Kcal/mol involving hydrogen bonds and hydrophobic interactions.
| Original language | English |
|---|---|
| Pages (from-to) | 2478-2482 |
| Number of pages | 5 |
| Journal | Journal of Chemical and Pharmaceutical Sciences |
| Volume | 9 |
| Issue number | 4 |
| State | Published - 2016 |
| Externally published | Yes |
Keywords
- 1 2 diaminopropane
- Bis-rhodanine
- HPV 16 E2 protein
- Hela cell line
- MTT assay
- Molecular docking