Synthesis, anti-microbial evaluation, and QSAR studies of 4-amino-3-hydroxy-naphthalene-1-sulfonic acid derivatives

Rajesh Kumar; Pradeep Kumar; Mahesh Kumar; Balasubramanian Narasimhan

doi:10.1007/s00044-011-9954-0

Synthesis, anti-microbial evaluation, and QSAR studies of 4-amino-3-hydroxy-naphthalene-1-sulfonic acid derivatives

Rajesh Kumar
, Pradeep Kumar
, Mahesh Kumar
, Balasubramanian Narasimhan

Maharshi Dayanand University

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

A series of 4-amino-3-hydroxy-naphthalene-1-sulfonic acid derivatives (1-18) was synthesized and tested in vitro for its anti-microbial potential. The results of antimicrobial studies indicated that derivatives having 3,4,5 trimethoxy (6) and 2,4 dichloro (17) groups on benzylidene amino portion were found to be most effective ones. The mt-QSAR model for anti-microbial activity revealed the importance of topological parameter, valence zero-order molecular connectivity index (⁰χ^v) in describing the antimicrobial activity of synthesized 4-amino-3-hydroxy-naphthalene-1-sulfonic acid derivatives.

Original language	English
Pages (from-to)	4301-4310
Number of pages	10
Journal	Medicinal Chemistry Research
Volume	21
Issue number	12
DOIs	https://doi.org/10.1007/s00044-011-9954-0
State	Published - 1 Dec 2012
Externally published	Yes

Bibliographical note

Publisher Copyright:
© Springer Science+Business Media, LLC 2012.

Keywords

Anti-microbial
Mt-QSAR
Naphthalene-1-sulfonic acid derivatives

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10.1007/s00044-011-9954-0

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AB - A series of 4-amino-3-hydroxy-naphthalene-1-sulfonic acid derivatives (1-18) was synthesized and tested in vitro for its anti-microbial potential. The results of antimicrobial studies indicated that derivatives having 3,4,5 trimethoxy (6) and 2,4 dichloro (17) groups on benzylidene amino portion were found to be most effective ones. The mt-QSAR model for anti-microbial activity revealed the importance of topological parameter, valence zero-order molecular connectivity index (0χv) in describing the antimicrobial activity of synthesized 4-amino-3-hydroxy-naphthalene-1-sulfonic acid derivatives.

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Synthesis, anti-microbial evaluation, and QSAR studies of 4-amino-3-hydroxy-naphthalene-1-sulfonic acid derivatives

Abstract

Bibliographical note

Keywords

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