Abstract
Six novel phenothiazine chalcone derivatives 2-7 were prepared and characterized by Spectral analysis. Molecular docking studies were carried out in order to assess the affinity between the synthesized compounds 2-7 and T315I mutated Bcr-Abel kinase protein. Compounds 4 and 7 showed very good docking scores and thereby serve as novel templates as T315I mutated Bcr-Abel kinase inhibitors.
| Original language | English |
|---|---|
| Pages (from-to) | 1139-1143 |
| Number of pages | 5 |
| Journal | Journal of Chemical and Pharmaceutical Sciences |
| Volume | 9 |
| Issue number | 3 |
| State | Published - 2016 |
| Externally published | Yes |
Keywords
- Chalcone
- Chronic myelogenous leukemia
- Condensation
- Molecular docking
- Phenothiazine