Synthesis and molecular docking studies of novel phenothiazine chalcone derivatives as T3151 mutated Bcr-Abl kinase inhibitors

Six novel phenothiazine chalcone derivatives 2-7 were prepared and characterized by Spectral analysis. Molecular docking studies were carried out in order to assess the affinity between the synthesized compounds 2-7 and T315I mutated Bcr-Abel kinase protein. Compounds 4 and 7 showed very good docking scores and thereby serve as novel templates as T315I mutated Bcr-Abel kinase inhibitors.