Synthesis and molecular docking studies of novel phenothiazine chalcone derivatives as T3151 mutated Bcr-Abl kinase inhibitors

K. Kanimozi, K. S. Ali Muhammad, R. Kumar, Subban Ravi

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Six novel phenothiazine chalcone derivatives 2-7 were prepared and characterized by Spectral analysis. Molecular docking studies were carried out in order to assess the affinity between the synthesized compounds 2-7 and T315I mutated Bcr-Abel kinase protein. Compounds 4 and 7 showed very good docking scores and thereby serve as novel templates as T315I mutated Bcr-Abel kinase inhibitors.

Original languageEnglish
Pages (from-to)1139-1143
Number of pages5
JournalJournal of Chemical and Pharmaceutical Sciences
Volume9
Issue number3
StatePublished - 2016
Externally publishedYes

Keywords

  • Chalcone
  • Chronic myelogenous leukemia
  • Condensation
  • Molecular docking
  • Phenothiazine

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