Synthesis and heparin-like biological activity of amino acid-based polymers

Alfonso Bentolila, Israel Vlodavsky, Christine Haloun, Abraham J. Domb

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Physiological functions are regulated by biological macromolecules and most of the biologically active macromolecules are charged linear polymers. Heparin is a natural polyanion composed of repeating disaccharide units of Glucosamine and uronic acid. Heparin is a potent anticoagulant, and also active as an antimethastatic and antiproliferative agent. Macromolecules based on N-acryl L-amino acids bearing hydrophobic or charged side groups, when arranged into a configuration determined by the chirality of the amino acid α-carbon may express heparin like biological activities. The absence of high acidic groups existing in heparin is compensated by some kind of lipophilic interaction.

Original languageEnglish
Pages (from-to)377-387
Number of pages11
JournalPolymers for Advanced Technologies
Volume11
Issue number8-12
DOIs
StatePublished - Aug 2000
Externally publishedYes

Fingerprint

Dive into the research topics of 'Synthesis and heparin-like biological activity of amino acid-based polymers'. Together they form a unique fingerprint.

Cite this