Synthesis and functionalization of persistent luminescence nanoparticles with small molecules and evaluation of their targeting ability

Thomas Maldiney, Gerardo Byk, Nicolas Wattier, Johanne Seguin, Raz Khandadash, Michel Bessodes, Cyrille Richard, Daniel Scherman

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

We have recently reported the design and use of inorganic nanoparticles with persistent luminescence properties. Such nanoparticles can be excited with a UV lamp for 2 min and emit light in the near-infrared area for dozen of minutes without any further excitation. This property is of particular interest for small animal optical imaging, since it avoids the autofluorescence of endogenous fluorophores which is one major problem encountered when using fluorescent probes. We report herein the synthesis of persistent luminescence nanoparticles (PLNPs) and their functionalization with two small targeting molecules: biotin and Rak-2. We provide characterization of each PLNP as well as preliminary evidence of the ability of PLNP-PEG-Biotin to target streptavidin and PLNP-PEG-Rak-2 to bind prostate cancer cells in vitro.

Original languageEnglish
Pages (from-to)102-107
Number of pages6
JournalInternational Journal of Pharmaceutics
Volume423
Issue number1
DOIs
StatePublished - 14 Feb 2012

Bibliographical note

Funding Information:
This work has been supported by the French National Agenc y (ANR) in the frame of its program in Nanosciences and Nanotechnologies (NATLURIM project no. ANR-08-NANO-025) and by the Region Ile-de-France (In Actio project no. I07-876/R). G. Byk is indebted to the Israel-USA Binational Science Foundation (BSF 1998378) and to the AFIRST Israel/France (programs of the French Ministry of Foreign Affairs and the Israeli Ministry of Sciences). R. Khandadash would like to express his sincere gratitude to the Israel Council for Higher Education for waiving the Converging Technologies Fellowship, to BIU President Scholarships for waiving fellowship and to the Marcus Center for Medicinal Chemistry for their continuous support.

Keywords

  • Binding
  • In vitro
  • PC-3
  • Persistent luminescence nanoparticles
  • Surface functionalization

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