Abstract
The present study describes the engineering of functional antibacterial nano/micro-particles and their utilization for antibiofouling applications. For this purpose, two
new vinylic monomers were synthesized, isothiouronium
methyl styrene (ITMS) and methyl styrene farmin (MSF).
Isothiouronium salts are well known for their antibacterials activities. The MSF monomer contains quaternary
ammonium and long alkyl chain groups, and therefore
is expected to possess efficient antibacterial and antibiofilm properties. The use of polymers is expected to enhance the efficacy of some existing antibacterial agents.
It is well known that the incorporation of the monomers
into polymeric particles significantly reduces their toxicity. The monomers were then polymerized by dispersion
co-polymerization mechanism to form crosslinked particles. Here, we describe the synthesis and properties of
three kinds of cross linked particles; polyisothiouronium
methyl styrene (PITMS) microparticles, polyisothiouronium methyl styrene nanoparticles (PITMS NPs) and
poly(methyl styrene farmin) nanoparticles (PMSF NPs).
The effect of various polymerization parameters on the
diameter and size distribution of the formed nano/microparticles has been elucidated. The antibacterial activity of
the optimal nano/micro-particles was illustrated for two
types of Gram-negative and two types of Gram-positive
bacteria pathogens; Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Listeria innocua, respec-
4 www.avidscience.com
Biomaterials
tively. Polyethylene terephthalate films were coated with a
thin layer of the PITMS and PMSF NPs and their antibiofouling properties was demonstrated. The formed films
reduced the viability of Listeria biofilm, therefore making
them an excellent candidates for non-fouling surfaces.
These new NPs could be utilized in a variety of industrial
applications, as a new type of antibacterial agent and antibiofilm additive, due to their promising antibacterial and
antibiofilm properties.
new vinylic monomers were synthesized, isothiouronium
methyl styrene (ITMS) and methyl styrene farmin (MSF).
Isothiouronium salts are well known for their antibacterials activities. The MSF monomer contains quaternary
ammonium and long alkyl chain groups, and therefore
is expected to possess efficient antibacterial and antibiofilm properties. The use of polymers is expected to enhance the efficacy of some existing antibacterial agents.
It is well known that the incorporation of the monomers
into polymeric particles significantly reduces their toxicity. The monomers were then polymerized by dispersion
co-polymerization mechanism to form crosslinked particles. Here, we describe the synthesis and properties of
three kinds of cross linked particles; polyisothiouronium
methyl styrene (PITMS) microparticles, polyisothiouronium methyl styrene nanoparticles (PITMS NPs) and
poly(methyl styrene farmin) nanoparticles (PMSF NPs).
The effect of various polymerization parameters on the
diameter and size distribution of the formed nano/microparticles has been elucidated. The antibacterial activity of
the optimal nano/micro-particles was illustrated for two
types of Gram-negative and two types of Gram-positive
bacteria pathogens; Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Listeria innocua, respec-
4 www.avidscience.com
Biomaterials
tively. Polyethylene terephthalate films were coated with a
thin layer of the PITMS and PMSF NPs and their antibiofouling properties was demonstrated. The formed films
reduced the viability of Listeria biofilm, therefore making
them an excellent candidates for non-fouling surfaces.
These new NPs could be utilized in a variety of industrial
applications, as a new type of antibacterial agent and antibiofilm additive, due to their promising antibacterial and
antibiofilm properties.
| Original language | American English |
|---|---|
| Title of host publication | Biomaterials |
| Subtitle of host publication | Open Educational Resources |
| Publisher | wiley |
| Chapter | 1 |
| Pages | 265-284 |
| Number of pages | 20 |
| ISBN (Electronic) | 9783527823963 |
| ISBN (Print) | 9783527346776 |
| DOIs | |
| State | Published - 2021 |
Publication series
| Name | UKM Literasi Informasi & Perpustakaan Unsyiah |
|---|
Bibliographical note
Publisher Copyright:© 2022 WILEY-VCH GmbH, Boschstr. 12, 69469 Weinheim, Germany All rights reserved.
Keywords
- Electrolyte
- Intermediate temperature solid oxide fuel cell (IT SOFC)
- Samarium doped ceria (SDC)
- Single step glycine nitrate process (GNP)