Synthesis and characterization of radiopaque magnetic core-shell nanoparticles for X-ray imaging applications

Anna Galperin, Shlomo Margel

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Radiopaque magnetic γ-Fe2O3/poly(2- methacryloyloxyethyl(2,3,5-triiodobenzoate)) core-shell nanoparticles of narrow size distribution were prepared by emulsion polymerization of the iodinated monomer 2-methacryloyloxyethyl(2,3,5-triiodobenzoate) in the presence of maghemite (γ-Fe2O3) nanoparticles of about 15 nm average diameter. The effect of the iodinated monomer concentration on the percent of the radiopaque shell coating has been elucidated. Characterization of these radiopaque core-shell particles was accomplished by methods such as FTIR, TGA, TEM, HRTEM, iodine analysis, and magnetic susceptibility measurements. The radiopacity of the dried and water dispersed core-shell nanoparticles was demonstrated by an imaging technique based on X-ray absorption usually used in hospitals. γ-Fe2O3 nanoparticles coated with a dextran shell are commonly used as contrast agents for magnetic resonance imaging (MRI). The present nanoparticles have similar core-shell structure substituting the dextran for the iodo polymer. These core-shell nanoparticles may therefore be useful as imaging contrast agents to detect various pathogenic zones and to observe different disease states in both modes: X-ray and MRI.

Original languageEnglish
Pages (from-to)490-498
Number of pages9
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Issue number2
StatePublished - Nov 2007


  • Coating
  • Nanomaterials
  • Nanomedicine
  • Radiopaque magnetic nanoparticles
  • X-ray imaging


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