TY - JOUR
T1 - Synthesis and characterization of radiopaque magnetic core-shell nanoparticles for X-ray imaging applications
AU - Galperin, Anna
AU - Margel, Shlomo
PY - 2007/11
Y1 - 2007/11
N2 - Radiopaque magnetic γ-Fe2O3/poly(2- methacryloyloxyethyl(2,3,5-triiodobenzoate)) core-shell nanoparticles of narrow size distribution were prepared by emulsion polymerization of the iodinated monomer 2-methacryloyloxyethyl(2,3,5-triiodobenzoate) in the presence of maghemite (γ-Fe2O3) nanoparticles of about 15 nm average diameter. The effect of the iodinated monomer concentration on the percent of the radiopaque shell coating has been elucidated. Characterization of these radiopaque core-shell particles was accomplished by methods such as FTIR, TGA, TEM, HRTEM, iodine analysis, and magnetic susceptibility measurements. The radiopacity of the dried and water dispersed core-shell nanoparticles was demonstrated by an imaging technique based on X-ray absorption usually used in hospitals. γ-Fe2O3 nanoparticles coated with a dextran shell are commonly used as contrast agents for magnetic resonance imaging (MRI). The present nanoparticles have similar core-shell structure substituting the dextran for the iodo polymer. These core-shell nanoparticles may therefore be useful as imaging contrast agents to detect various pathogenic zones and to observe different disease states in both modes: X-ray and MRI.
AB - Radiopaque magnetic γ-Fe2O3/poly(2- methacryloyloxyethyl(2,3,5-triiodobenzoate)) core-shell nanoparticles of narrow size distribution were prepared by emulsion polymerization of the iodinated monomer 2-methacryloyloxyethyl(2,3,5-triiodobenzoate) in the presence of maghemite (γ-Fe2O3) nanoparticles of about 15 nm average diameter. The effect of the iodinated monomer concentration on the percent of the radiopaque shell coating has been elucidated. Characterization of these radiopaque core-shell particles was accomplished by methods such as FTIR, TGA, TEM, HRTEM, iodine analysis, and magnetic susceptibility measurements. The radiopacity of the dried and water dispersed core-shell nanoparticles was demonstrated by an imaging technique based on X-ray absorption usually used in hospitals. γ-Fe2O3 nanoparticles coated with a dextran shell are commonly used as contrast agents for magnetic resonance imaging (MRI). The present nanoparticles have similar core-shell structure substituting the dextran for the iodo polymer. These core-shell nanoparticles may therefore be useful as imaging contrast agents to detect various pathogenic zones and to observe different disease states in both modes: X-ray and MRI.
KW - Coating
KW - Nanomaterials
KW - Nanomedicine
KW - Radiopaque magnetic nanoparticles
KW - X-ray imaging
UR - http://www.scopus.com/inward/record.url?scp=35548988473&partnerID=8YFLogxK
U2 - 10.1002/jbm.b.30821
DO - 10.1002/jbm.b.30821
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C2 - 17465021
AN - SCOPUS:35548988473
SN - 1552-4973
VL - 83
SP - 490
EP - 498
JO - Journal of Biomedical Materials Research - Part B Applied Biomaterials
JF - Journal of Biomedical Materials Research - Part B Applied Biomaterials
IS - 2
ER -