Synthesis and characterization of new radiopaque microspheres by the dispersion polymerization of an lodinated acrylate monomer for X-ray imaging applications

Anna Galperin, Shlomo Margel

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

Radiopaque microspheres of sizes ranging from 0.2 to 1.4 μm were formed by the dispersion polymerization of the monomer 2-methacryloyloxyethyl(2,3,5- triiodo-benzoate) in 2-methoxyethanol. The effects of various polymerization parameters, including the monomer concentration, initiator type and concentration, and stabilizer molecular weight and concentration, on the molecular weight, size, and size distribution of the particles were elucidated. The characterization of these iodinated microspheres was accomplished with routine methods such as Fourier transform infrared, nuclear magnetic resonance, thermogravimetric analysis, differential scanning calorimetry, gel permeation chromatography, scanning electron microscopy, Brunauer-Emmett-Teller measurements, and elemental analysis. Because of the presence of iodine atoms in these microspheres, they were expected to possess a radiopaque nature. The radiopacity of these particles dispersed in water and in the dry state was demonstrated with an imaging technique based on X-ray absorption usually used in hospitals. These novel radiopaque microspheres may be used for different X-ray imaging needs, such as blood pooling, body organs, embolization, dental compositions, implants, prostheses, and nanocomposites.

Original languageEnglish
Pages (from-to)3859-3868
Number of pages10
JournalJournal of Polymer Science, Part A: Polymer Chemistry
Volume44
Issue number12
DOIs
StatePublished - 15 Jun 2006

Keywords

  • Dispersion polymerization
  • Particle size distribution
  • Radical polymerization
  • Radiopaque microspheres
  • X-ray imaging

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