Synthesis and characterization of dual modality (CT/MRI) core-shell microparticles for embolization purposes

Aviv Hagit; Bartling Soenke; Budjan Johannes; Margel Shlomo

doi:10.1021/bm100251s

Synthesis and characterization of dual modality (CT/MRI) core-shell microparticles for embolization purposes

Aviv Hagit, Bartling Soenke, Budjan Johannes, Margel Shlomo

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Core P(MAOETIB-GMA) microparticles of 40-200 μ m were prepared by suspension copolymerization of the iodinated monomer 2-methacryloyloxyethyl (2,3,5-triiodobenzoate), MAOETIB, with a low concentration of the monomer glycidyl methacrylate, GMA, which formed hydrophilic surfaces on the particles. Magnetic ã-Fe2O3/P(MAOETIB-GMA) core-shell microparticles were prepared by coating the aforementioned core particles through nucleation of iron oxide nanoparticles on the surfaces of the P(MAOETIB-GMA) particles. This was followed by stepwise growth of thin iron oxide layers. The radiopacity and magnetism of these particles were demonstrated in vitro by CT and MRI. In vivo embolization capabilities of these first multimodal visible embolization particles were demonstrated in a rat's kidney tumor embolization model.

Original language	English
Pages (from-to)	1600-1607
Number of pages	8
Journal	Biomacromolecules
Volume	11
Issue number	6
DOIs	https://doi.org/10.1021/bm100251s
State	Published - 14 Jun 2010

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abstract = "Core P(MAOETIB-GMA) microparticles of 40-200 μ m were prepared by suspension copolymerization of the iodinated monomer 2-methacryloyloxyethyl (2,3,5-triiodobenzoate), MAOETIB, with a low concentration of the monomer glycidyl methacrylate, GMA, which formed hydrophilic surfaces on the particles. Magnetic {\~a}-Fe2O3/P(MAOETIB-GMA) core-shell microparticles were prepared by coating the aforementioned core particles through nucleation of iron oxide nanoparticles on the surfaces of the P(MAOETIB-GMA) particles. This was followed by stepwise growth of thin iron oxide layers. The radiopacity and magnetism of these particles were demonstrated in vitro by CT and MRI. In vivo embolization capabilities of these first multimodal visible embolization particles were demonstrated in a rat's kidney tumor embolization model.",

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AU - Hagit, Aviv

AU - Soenke, Bartling

AU - Johannes, Budjan

AU - Shlomo, Margel

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Synthesis and characterization of dual modality (CT/MRI) core-shell microparticles for embolization purposes

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