Synthesis and characterization of Bi2O3/HSA core-shell nanoparticles for X-ray imaging applications

Hagit Aviv, Soenke Bartling, Igor Grinberg, Shlomo Margel

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Bismuth oxide nanoparticles of 12.1 ± 3.0 nm diameter were prepared by thermal decomposition of bismuth acetate dissolved in ethylene glycol in the presence of an oxidizing agent. Functionalization and stabilization of the hydrophobic Bi2O3 nanoparticles was accomplished by coating these core nanoparticles with human serum albumin (HSA), via a precipitation process. The formed Bi2O3/HSA core-shell nanoparticles were of 15.2 ± 3.5 nm diameter. Elemental analysis measurements indicated that the bismuth weight % of the Bi2O 3/HSA core-shell nanoparticles is 72.9. The crystalline structure of these nanoparticles was examined by XRD. The radiopacity of these nanoparticles was demonstrated in vitro and in vivo by a CT scanner. In ovo and in vivo trials proved the safety of these Bi2O3/HSA core-shell nanoparticles. In the future, we plan to extend this study particularly for molecular imaging applications.

Original languageEnglish
Pages (from-to)131-138
Number of pages8
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume101 B
Issue number1
StatePublished - Jan 2013


  • CT contrast agents
  • HSA coating
  • bismuth oxide nanoparticles
  • radiopacity
  • thermal decomposition


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