Synthesis and characterization of biodegradable copolyesters and copolyanhydrides prepared from fumaric and succinic acid trimers and oligomers

Shimon Ben-Shabat, Omar Elmalak, Abraham Nyska, Abraham J. Domb

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

A series of new biodegradable copolymers and copolyanhydrides built of trimers of fumaric and succinic acid and propylene glycol, covering a wide range of compositions, were prepared and characterized for use as drug carriers. The polymers were found to degrade within a period of weeks. Polyanhydrides loaded with ibuprofen as a model drug released the drug for a period of one week, while the polyesters released the drug for more then 30 days. The biocompatibility and the rate of evacuation of trimer-based polymers of fumaric and succinic acids were investigated in rats. All polymers were found compatible when implanted in mice.

Original languageEnglish
Pages (from-to)411-420
Number of pages10
JournalIsrael Journal of Chemistry
Volume45
Issue number4
DOIs
StatePublished - 2005
Externally publishedYes

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