TY - JOUR
T1 - Synthesis and characterization of biodegradable copolyesters and copolyanhydrides prepared from fumaric and succinic acid trimers and oligomers
AU - Ben-Shabat, Shimon
AU - Elmalak, Omar
AU - Nyska, Abraham
AU - Domb, Abraham J.
PY - 2005
Y1 - 2005
N2 - A series of new biodegradable copolymers and copolyanhydrides built of trimers of fumaric and succinic acid and propylene glycol, covering a wide range of compositions, were prepared and characterized for use as drug carriers. The polymers were found to degrade within a period of weeks. Polyanhydrides loaded with ibuprofen as a model drug released the drug for a period of one week, while the polyesters released the drug for more then 30 days. The biocompatibility and the rate of evacuation of trimer-based polymers of fumaric and succinic acids were investigated in rats. All polymers were found compatible when implanted in mice.
AB - A series of new biodegradable copolymers and copolyanhydrides built of trimers of fumaric and succinic acid and propylene glycol, covering a wide range of compositions, were prepared and characterized for use as drug carriers. The polymers were found to degrade within a period of weeks. Polyanhydrides loaded with ibuprofen as a model drug released the drug for a period of one week, while the polyesters released the drug for more then 30 days. The biocompatibility and the rate of evacuation of trimer-based polymers of fumaric and succinic acids were investigated in rats. All polymers were found compatible when implanted in mice.
UR - http://www.scopus.com/inward/record.url?scp=27844534106&partnerID=8YFLogxK
U2 - 10.1560/edr4-8fc1-cq8m-j6rl
DO - 10.1560/edr4-8fc1-cq8m-j6rl
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AN - SCOPUS:27844534106
SN - 0021-2148
VL - 45
SP - 411
EP - 420
JO - Israel Journal of Chemistry
JF - Israel Journal of Chemistry
IS - 4
ER -