Abstract
Synthesis of some novel thiazole hydrazine derivatives from thiosemicarbazones of salicylaldehyde and 5-chlorosalicylaldehyde with phenacyl bromide in ethanol under reflux condition is reported. The synthesized compounds were characterized by spectral analysis and further screened against-S. aureus, E. coli, P. aeruginosa, S. pyogenus bacteria, and against C. albicans, A. clavatus, and A. niger fungal strains. Most of the compounds were active against E. coli and C. albicans. Antimalarial screening against Plasmodium falciparum showed moderate to the good activity of the synthesized compounds but less than the standard quinine. One of the synthesized compounds (4c) exhibited promising antimalarial activity against Plasmodium falciparum with IC50 close to the standard quinine.
| Original language | English |
|---|---|
| Pages (from-to) | 1846-1855 |
| Number of pages | 10 |
| Journal | Letters in Applied NanoBioScience |
| Volume | 10 |
| Issue number | 1 |
| DOIs | |
| State | Published - 30 Mar 2021 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2020 by the authors.
Funding
Authors are thankful to the Principal, Deogiri College, Aurangabad, for providing necessary laboratory facilities and the Director, Sophisticated Analytical and Instrumentation Facilities (SAIF), Chandigarh, for spectral data. One of the authors, VAG expresses special thanks to the Council of Scientific and Industrial Research (CSIR), New Delhi, India, for providing financial assistance under Junior Research Fellowship [File No. 08/582(0007) / 2017-EMR-I].
| Funders | Funder number |
|---|---|
| Chandigarh | |
| Council of Scientific and Industrial Research, India | 08/582(0007) / 2017-EMR-I |
Keywords
- antimalarial
- antimicrobial
- thiazole hydrazines