Synthesis and biological evaluation of fentanyl acrylic derivatives

Shaohua Li, Devora Cohen-Karni, Marina Kovaliov, Nestor Tomycz, Boyle Cheng, Donald Whiting, Saadyah Averick

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The synthesis of novel fentanyl acrylate derivatives via bromo-fentanyl using Heck coupling is described. The synthesis is concise and represents an efficient and useful method for functionalizing fentanyl for medicinal chemistry investigations. The agonistic and analgesic activities are evaluated by Mu opioid receptor activation and hot plate assays in mice.

Original languageEnglish
Pages (from-to)20015-20019
Number of pages5
JournalRSC Advances
Volume7
Issue number32
DOIs
StatePublished - 2017
Externally publishedYes

Bibliographical note

Publisher Copyright:
© The Royal Society of Chemistry.

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