Synthesis and anticancer activity of novel chiral D-glucose derived bis-imidazoles and their analogs

Chenghe Zhou, Alfred Hassner

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

A series of novel D-glucose derived bis-imidazoles and their analogs, which possess potential in bioorganic and supramolecular chemistry, were designed and synthesized from methyl α-D-glucoside through protection, bis-bromination, N-alkylation and deprotection. All new compounds were characterized by HRMS, 1H, 13C and DEPT NMR spectroscopy as well as elemental analysis. The 1H-1H and 1H-13C 2D NMR spectra for some compounds were also recorded. Some regular features of 13C and 1H NMR spectra were summarized. The anticancer activity of some compounds was evaluated.

Original languageEnglish
Pages (from-to)313-326
Number of pages14
JournalCarbohydrate Research
Volume333
Issue number4
DOIs
StatePublished - 19 Jul 2001

Bibliographical note

Funding Information:
Support of this research from the Fred and Barbara Kort Sino-Israel Postdoctoral Fellowship Program as well as from the Marcus Center of Medicinal Chemistry is gratefully acknowledged. The authors thank Dr Hugo E. Gottlieb for valuable help with the NMR spectra.

Funding

Support of this research from the Fred and Barbara Kort Sino-Israel Postdoctoral Fellowship Program as well as from the Marcus Center of Medicinal Chemistry is gratefully acknowledged. The authors thank Dr Hugo E. Gottlieb for valuable help with the NMR spectra.

FundersFunder number
Fred and Barbara Kort Sino-Israel Postdoctoral Fellowship Program

    Keywords

    • Biological activity
    • Carbohydrates
    • Glucosides
    • H and C NMR
    • Imidazoles
    • Organic synthesis

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