Abstract
A series of novel D-glucose derived bis-imidazoles and their analogs, which possess potential in bioorganic and supramolecular chemistry, were designed and synthesized from methyl α-D-glucoside through protection, bis-bromination, N-alkylation and deprotection. All new compounds were characterized by HRMS, 1H, 13C and DEPT NMR spectroscopy as well as elemental analysis. The 1H-1H and 1H-13C 2D NMR spectra for some compounds were also recorded. Some regular features of 13C and 1H NMR spectra were summarized. The anticancer activity of some compounds was evaluated.
Original language | English |
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Pages (from-to) | 313-326 |
Number of pages | 14 |
Journal | Carbohydrate Research |
Volume | 333 |
Issue number | 4 |
DOIs | |
State | Published - 19 Jul 2001 |
Bibliographical note
Funding Information:Support of this research from the Fred and Barbara Kort Sino-Israel Postdoctoral Fellowship Program as well as from the Marcus Center of Medicinal Chemistry is gratefully acknowledged. The authors thank Dr Hugo E. Gottlieb for valuable help with the NMR spectra.
Funding
Support of this research from the Fred and Barbara Kort Sino-Israel Postdoctoral Fellowship Program as well as from the Marcus Center of Medicinal Chemistry is gratefully acknowledged. The authors thank Dr Hugo E. Gottlieb for valuable help with the NMR spectra.
Funders | Funder number |
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Fred and Barbara Kort Sino-Israel Postdoctoral Fellowship Program |
Keywords
- Biological activity
- Carbohydrates
- Glucosides
- H and C NMR
- Imidazoles
- Organic synthesis