Synovial VLA-1+ T cells display an oligoclonal and partly distinct repertoire in rheumatoid and psoriatic arthritis

Itamar Goldstein, Amos J. Simon, Shomron Ben Horin, Sarit Matzri, Alexander Koltakov, Pnina Langevitz, Gideon Rechavi, Ninette Amariglio, Ilan Bank

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


VLA-1 integrin expressing T cells are more frequent in inflammatory synovial fluids (SF) compared to peripheral blood. Recent studies suggest that VLA-1 expression mainly marks IFNγ+ T cells while excluding both IL-4+ and regulatory FoxP3+ T cells. To further characterize the TCR repertoire of the potentially pathogenic VLA-1+ IFNγ+ T cells, isolated from SF of adult patients with rheumatoid and psoriatic arthritis, we determined the complementarity determining region (CDR)3 spectratypes. Here we show in a cohort of 9 patients that VLA-1+ T cells display a perturbed repertoire that, moreover, differs from that of VLA-1- synovial T cells and even VLA-1+ PB T cells. Importantly, random sequencing of the CDR3 region of the TCR variable β (BV) 6.1 gene of both VLA-1+ and VLA-1- synovial T cells, in one patient, revealed that their sequences were by and large different (29 out of 33 clones). Thus, our results imply that VLA-1+ T cells that infiltrate into inflamed joints represent a partly distinct and highly oligoclonal population of Th1 cells, probably selected by unique antigens.

Original languageEnglish
Pages (from-to)75-84
Number of pages10
JournalClinical Immunology
Issue number1
StatePublished - Jul 2008
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported in part by an investigator initiated research grant from Biogen Idec to I.B. G.R. holds the Djerasi Chair for Oncology (Sackler School of Medicine, Tel Aviv University). Part of this work was performed in partial fulfillment of the requirements of the MSc of S. Matzri at the Sackler School of Medicine (Tel Aviv University).


  • CDR3 length diversity
  • Effector and memory T cells
  • Inflammatory arthritis
  • Integrin
  • T cell receptor (TCR)
  • TCR repertoire
  • Very late activation antigen (VLA-1)


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