Synergistic activity between a spinach-derived natural antioxidant (NAO) and commercial antioxidants in a variety of oxidation systems

Ravit Hait-Darshan; Shlomo Grossman; Margalit Bergman; Mordehai Deutsch; Naomi Zurgil

doi:10.1016/j.foodres.2008.11.006

Synergistic activity between a spinach-derived natural antioxidant (NAO) and commercial antioxidants in a variety of oxidation systems

Ravit Hait-Darshan
, Shlomo Grossman
, Margalit Bergman
, Mordehai Deutsch
, Naomi Zurgil

Department of Physics - at Bar-Ilan University

Bar-Ilan University

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Recently, there has been great interest in the potential health benefits of foods containing polyphenols, especially from plants, due to their antioxidant content. Natural antioxidant (NAO) is a unique, powerful antioxidant which was isolated in our lab from spinach leaves. The main goal of this study was to examine potential synergistic activity in combinations of NAO and commercial antioxidants. The antioxidant activity was tested in several in vitro systems including fatty acid and fat oxidation and also in cancer cell lines. We used the unique optical live cell array (LCA) technology to monitor the generation of reactive oxygen species (ROS) in single cells over time. NAO was combined with selected commercial antioxidants, and synergistic activity that reduced ROS generation was found with three polyphenols - ferulic acid, caffeic acid, and epigallocatechin-3-gallate (EGCG). These findings demonstrate the importance of using antioxidant 'cocktails' which may enhance medical effects in many kinds of diseases, including cardiovascular diseases and cancer.

Original language	English
Pages (from-to)	246-253
Number of pages	8
Journal	Food Research International
Volume	42
Issue number	2
DOIs	https://doi.org/10.1016/j.foodres.2008.11.006
State	Published - Mar 2009

Bibliographical note

Funding Information:
The authors thank Ms. Yana Shafran and Dr. Elena Afrimzon for technical assistance. This research was partly supported by the Vinograd Foundation, the Lewitt-Schwartz Chair, and the Yeshaya Horowitz Association.

Funding

The authors thank Ms. Yana Shafran and Dr. Elena Afrimzon for technical assistance. This research was partly supported by the Vinograd Foundation, the Lewitt-Schwartz Chair, and the Yeshaya Horowitz Association.

Funders
Vinograd Foundation
Yeshaya Horowitz Association

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Antioxidant
Caffeic acid
EGCG
Ferulic acid
NAO
ROS

Access to Document

10.1016/j.foodres.2008.11.006

Cite this

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title = "Synergistic activity between a spinach-derived natural antioxidant (NAO) and commercial antioxidants in a variety of oxidation systems",

abstract = "Recently, there has been great interest in the potential health benefits of foods containing polyphenols, especially from plants, due to their antioxidant content. Natural antioxidant (NAO) is a unique, powerful antioxidant which was isolated in our lab from spinach leaves. The main goal of this study was to examine potential synergistic activity in combinations of NAO and commercial antioxidants. The antioxidant activity was tested in several in vitro systems including fatty acid and fat oxidation and also in cancer cell lines. We used the unique optical live cell array (LCA) technology to monitor the generation of reactive oxygen species (ROS) in single cells over time. NAO was combined with selected commercial antioxidants, and synergistic activity that reduced ROS generation was found with three polyphenols - ferulic acid, caffeic acid, and epigallocatechin-3-gallate (EGCG). These findings demonstrate the importance of using antioxidant 'cocktails' which may enhance medical effects in many kinds of diseases, including cardiovascular diseases and cancer.",

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author = "Ravit Hait-Darshan and Shlomo Grossman and Margalit Bergman and Mordehai Deutsch and Naomi Zurgil",

note = "Funding Information: The authors thank Ms. Yana Shafran and Dr. Elena Afrimzon for technical assistance. This research was partly supported by the Vinograd Foundation, the Lewitt-Schwartz Chair, and the Yeshaya Horowitz Association.",

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AU - Deutsch, Mordehai

AU - Zurgil, Naomi

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Synergistic activity between a spinach-derived natural antioxidant (NAO) and commercial antioxidants in a variety of oxidation systems

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

Access to Document

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Cite this