TY - CHAP
T1 - Synchronization Of pallidal activity in the MPTP primate model of parkinsonism is not limited to oscillatory activity
AU - Heimer, G.
AU - Bar Gad, I.
AU - Goldberg, J. A.
AU - Bergman, H.
PY - 2002
Y1 - 2002
N2 - Early studies of the neuronal activity of basal ganglia neurons in the MPTP primate model of the disease (Miller and DeLong, 1987;Filion and Tremblay, 1991) and in human patients undergoing streotaxic surgeries (see reviews in (Lang and Lozano, 1998a;Lang and Lozano, 1998b;Vitek and Giroux, 2000)) focused on changes in the firing rates of these neurons. Firing patterns in the basal ganglia networks are also dramatically altered following MPTP-treatment. There is an increase in the percentage of neurons that discharge in bursts. These bursts are either irregular or oscillatory (periodic) and have been found in the striatum (Raz et al., 1996), STN (Bergman et al., 1994), GPe and GPi (Miller and DeLong, 1987;Filion and Tremblay, 1991;Boraud et al., 1998; Raz et al., 2000;Bergman et al., 1994;Nini et al., 1995;Wichmann et al., 1999) and recently also in primary motor cortex (Goldberg et. al, this volume). Physiological studies in human PD patients have found cells whose discharge is modulated in the tremor frequency range in the thalamus, in GPi and in the STN (Hutchison et al., 1997; Lenz et al., 1988; Magnin et al., 2000).
AB - Early studies of the neuronal activity of basal ganglia neurons in the MPTP primate model of the disease (Miller and DeLong, 1987;Filion and Tremblay, 1991) and in human patients undergoing streotaxic surgeries (see reviews in (Lang and Lozano, 1998a;Lang and Lozano, 1998b;Vitek and Giroux, 2000)) focused on changes in the firing rates of these neurons. Firing patterns in the basal ganglia networks are also dramatically altered following MPTP-treatment. There is an increase in the percentage of neurons that discharge in bursts. These bursts are either irregular or oscillatory (periodic) and have been found in the striatum (Raz et al., 1996), STN (Bergman et al., 1994), GPe and GPi (Miller and DeLong, 1987;Filion and Tremblay, 1991;Boraud et al., 1998; Raz et al., 2000;Bergman et al., 1994;Nini et al., 1995;Wichmann et al., 1999) and recently also in primary motor cortex (Goldberg et. al, this volume). Physiological studies in human PD patients have found cells whose discharge is modulated in the tremor frequency range in the thalamus, in GPi and in the STN (Hutchison et al., 1997; Lenz et al., 1988; Magnin et al., 2000).
M3 - Chapter
SN - 978-1-4613-5207-5
T3 - Advances in Behavioral Biology
SP - 29
EP - 34
BT - The Basal Ganglia VII
A2 - Nicholson, L. F. B.
A2 - Faull, R. L. M.
PB - Springer
ER -
