Surface-enhanced raman scattering tags for rapid and homogeneous detection of circulating tumor cells in the presence of human whole blood

Michael Y. Sha; Hongxia Xu; Michael J. Natan; Remy Cromer

doi:10.1021/ja804494m

Surface-enhanced raman scattering tags for rapid and homogeneous detection of circulating tumor cells in the presence of human whole blood

Michael Y. Sha
, Hongxia Xu
, Michael J. Natan
, Remy Cromer

Oxonica, Inc.

Research output: Contribution to journal › Article › peer-review

320 Scopus citations

Abstract

A novel, homogeneous SERS-based cell detection assay was developed for rapid and direct enumeration of circulating tumor cells in the presence of whole blood. Magnetic beads and SERS tags were respectively conjugated to EpCAM and her2 antibodies for the capture and detection of approximately 50 tumor cells/mL in the presence of whole blood in less than 1 h.

Original language	English
Pages (from-to)	17214-17215
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	130
Issue number	51
DOIs	https://doi.org/10.1021/ja804494m
State	Published - 24 Dec 2008
Externally published	Yes

Funding

Funders	Funder number
National Cancer Institute	U54CA119338

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10.1021/ja804494m

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title = "Surface-enhanced raman scattering tags for rapid and homogeneous detection of circulating tumor cells in the presence of human whole blood",

abstract = "A novel, homogeneous SERS-based cell detection assay was developed for rapid and direct enumeration of circulating tumor cells in the presence of whole blood. Magnetic beads and SERS tags were respectively conjugated to EpCAM and her2 antibodies for the capture and detection of approximately 50 tumor cells/mL in the presence of whole blood in less than 1 h.",

author = "Sha, \{Michael Y.\} and Hongxia Xu and Natan, \{Michael J.\} and Remy Cromer",

year = "2008",

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doi = "10.1021/ja804494m",

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AU - Sha, Michael Y.

AU - Xu, Hongxia

AU - Natan, Michael J.

AU - Cromer, Remy

PY - 2008/12/24

Y1 - 2008/12/24

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AB - A novel, homogeneous SERS-based cell detection assay was developed for rapid and direct enumeration of circulating tumor cells in the presence of whole blood. Magnetic beads and SERS tags were respectively conjugated to EpCAM and her2 antibodies for the capture and detection of approximately 50 tumor cells/mL in the presence of whole blood in less than 1 h.

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Surface-enhanced raman scattering tags for rapid and homogeneous detection of circulating tumor cells in the presence of human whole blood

Abstract

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