Surface binding inhibitors of the SCF-KIT protein-protein interaction

David Marguiles, Yarden Opatowsky, Steven Fletcher, Ishu Saraogi, Lun K. Tsou, Sourav Saha, Irit Lax, Joseph Schelessinger, Andrew D. Hamilton

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Agents of disruption. Different classes of synthetic protein surface binders were prepared in an attempt to disrupt the oncogenic interaction of the receptor tyrosine kinase, KIT, with its ligand, stem cell factor (SCF). We report potent scaffolds, such as that illustrated in the figure, capable of interfering with the binding of SCF to the extracellular ligand-binding domain of KIT and disrupting cell signaling stimulation.
Original languageEnglish
Pages (from-to)1955-1958
Number of pages4
JournalChemBioChem
Volume10
Issue number12
DOIs
StatePublished - 17 Aug 2009
Externally publishedYes

Keywords

  • Drug design
  • Protein-protein interactions
  • SCF-KIT
  • Supramolecular chemistry
  • Synthetic inhibitors

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