TY - JOUR
T1 - Surface binding inhibitors of the SCF-KIT protein-protein interaction
AU - Marguiles, David
AU - Opatowsky, Yarden
AU - Fletcher, Steven
AU - Saraogi, Ishu
AU - Tsou, Lun K.
AU - Saha, Sourav
AU - Lax, Irit
AU - Schelessinger, Joseph
AU - Hamilton, Andrew D.
PY - 2009/8/17
Y1 - 2009/8/17
N2 - Agents of disruption. Different classes of synthetic protein surface binders were prepared in an attempt to disrupt the oncogenic interaction of the receptor tyrosine kinase, KIT, with its ligand, stem cell factor (SCF). We report potent scaffolds, such as that illustrated in the figure, capable of interfering with the binding of SCF to the extracellular ligand-binding domain of KIT and disrupting cell signaling stimulation.
AB - Agents of disruption. Different classes of synthetic protein surface binders were prepared in an attempt to disrupt the oncogenic interaction of the receptor tyrosine kinase, KIT, with its ligand, stem cell factor (SCF). We report potent scaffolds, such as that illustrated in the figure, capable of interfering with the binding of SCF to the extracellular ligand-binding domain of KIT and disrupting cell signaling stimulation.
KW - Drug design
KW - Protein-protein interactions
KW - SCF-KIT
KW - Supramolecular chemistry
KW - Synthetic inhibitors
UR - http://www.scopus.com/inward/record.url?scp=70349559761&partnerID=8YFLogxK
U2 - 10.1002/cbic.200900079
DO - 10.1002/cbic.200900079
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C2 - 19637142
SN - 1439-4227
VL - 10
SP - 1955
EP - 1958
JO - ChemBioChem
JF - ChemBioChem
IS - 12
ER -