Surface analysis of biodegradable poly(anhydride) copolymers by ToF-SIMS

M. C. Davis, R. A.P. Lynn, R. Langer, A. Domb

Research output: Contribution to journalConference articlepeer-review


The polyanhydrides are under development as clinical materials including drug delivery applications. This paper examines the surface chemical structure of a range of aliphation and aromatic polyanhydride homopolymers and copolymers currently under the development for biomedical devices. Time-of-flight secondary ion mass spectrometry (ToF-SIMS) analysis reveal diagnostic data of all types of repeat unit examined, providing a detailed insight into the molecular structure of the interface. Evidence of surface oligomers is presented on hydrolysed polymers.

Original languageEnglish
Pages (from-to)888
Number of pages1
JournalPolymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering
StatePublished - 1990
Externally publishedYes
EventProceedings of the ACS Division of Polymeric Materials: Science and Engineering - Boston, MA, USA
Duration: 1 Apr 19901 Apr 1990


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