Abstract
Bacterial urinary tract infections resulting from prolonged patient catheterization have become a major health problem. One of the major issues is bacterial resistance to antibiotic treatments due to biofilm formation inside the catheters, thus enhancing the search for alternative treatments. In the present study, a device containing a piezo element capable of transmitting low-frequency surface acoustic waves (SAW) onto the indwelling catheter was used. The SAW were able to eradicate biofilm-residing bacteria by 485% when applied simultaneously with an antibiotic in three clinically relevant species, viz. Escherichia coli, Staphylococcus epidermidis and Pseudomonas aeruginosa. Moreover, transcriptome analysis revealed that SAW can alter the transcription pattern of P. aeruginosa, suggesting that this signal can be specifically sensed by the bacterium.
Original language | English |
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Pages (from-to) | 701-711 |
Number of pages | 11 |
Journal | Biofouling |
Volume | 27 |
Issue number | 7 |
DOIs | |
State | Published - Aug 2011 |
Bibliographical note
Funding Information:This work was supported by a Nofar grant to EB from the Israel Ministry of Industry, Trade and Labor. The authors thank H. Jacob, I. Zumeris, H. Raskin, and J. Zumeris for helpful discussion and technical assistance.
Funding
This work was supported by a Nofar grant to EB from the Israel Ministry of Industry, Trade and Labor. The authors thank H. Jacob, I. Zumeris, H. Raskin, and J. Zumeris for helpful discussion and technical assistance.
Funders | Funder number |
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Ministry of Industry, Trade and Labor |
Keywords
- Antibiotics
- Biofilm
- Surface acoustic waves
- Transcriptome analysis