TY - JOUR
T1 - Supplementary Motor Area Activity Differs in Parkinson’s Disease with and without Freezing of Gait
AU - Marquez, J. Sebastian
AU - Bartsch, Ronny P.
AU - Günther, Moritz
AU - Hasan, S. M.Shafiul
AU - Koren, Or
AU - Plotnik, Meir
AU - Bai, Ou
N1 - Publisher Copyright:
Copyright © 2023 J. Sebastian Marquez et al.
PY - 2023
Y1 - 2023
N2 - The study aimed to investigate the neural changes that differentiate Parkinson’s disease patients with freezing of gait and age-matched controls, using ambulatory electroencephalography event-related features. Compared to controls, definite freezers exhibited significantly less alpha desynchronization at the motor cortex about 300 ms before and after the start of overground walking and decreased low-beta desynchronization about 300 ms before and about 300 and 700 ms after walking onset. The late slope of motor potentials also differed in the sensory and motor areas between groups of controls, definite, and probable freezers. This difference was found both in preparation and during the execution of normal walking. The average frontal peak of motor potential was also found to be largely reduced in the definite freezers compared with the probable freezers and controls. These findings provide valuable insights into the underlying structures that are affected in patients with freezing of gait, which could be used to tailor drug development and personalize drug care for disease subtypes. In addition, the study’s findings can help in the evaluation and validation of nonpharmacological therapies for patients with Parkinson’s disease.
AB - The study aimed to investigate the neural changes that differentiate Parkinson’s disease patients with freezing of gait and age-matched controls, using ambulatory electroencephalography event-related features. Compared to controls, definite freezers exhibited significantly less alpha desynchronization at the motor cortex about 300 ms before and after the start of overground walking and decreased low-beta desynchronization about 300 ms before and about 300 and 700 ms after walking onset. The late slope of motor potentials also differed in the sensory and motor areas between groups of controls, definite, and probable freezers. This difference was found both in preparation and during the execution of normal walking. The average frontal peak of motor potential was also found to be largely reduced in the definite freezers compared with the probable freezers and controls. These findings provide valuable insights into the underlying structures that are affected in patients with freezing of gait, which could be used to tailor drug development and personalize drug care for disease subtypes. In addition, the study’s findings can help in the evaluation and validation of nonpharmacological therapies for patients with Parkinson’s disease.
UR - http://www.scopus.com/inward/record.url?scp=85171856518&partnerID=8YFLogxK
U2 - 10.1155/2023/5033835
DO - 10.1155/2023/5033835
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C2 - 37701070
AN - SCOPUS:85171856518
SN - 2090-8083
VL - 2023
JO - Parkinson's Disease
JF - Parkinson's Disease
M1 - 5033835
ER -