Successful multi-site measurement of antisaccade performance deficits in schizophrenia

Allen D. Radant; Dorcas J. Dobie; Monica E. Calkins; Ann Olincy; David L. Braff; Kristin S. Cadenhead; Robert Freedman; Michael F. Green; Tiffany A. Greenwood; Raquel E. Gur; Gregory A. Light; Sean P. Meichle; Jim Mintz; Keith H. Nuechterlein; Nicholas J. Schork; Larry J. Seidman; Larry J. Siever; Jeremy M. Silverman; William S. Stone; Neal R. Swerdlow; Ming T. Tsuang; Bruce I. Turetsky; Debby W. Tsuang

doi:10.1016/j.schres.2006.08.010

Successful multi-site measurement of antisaccade performance deficits in schizophrenia

Allen D. Radant, Dorcas J. Dobie, Monica E. Calkins, Ann Olincy, David L. Braff, Kristin S. Cadenhead, Robert Freedman, Michael F. Green, Tiffany A. Greenwood, Raquel E. Gur, Gregory A. Light, Sean P. Meichle, Jim Mintz, Keith H. Nuechterlein, Nicholas J. Schork, Larry J. Seidman, Larry J. Siever, Jeremy M. Silverman, William S. Stone, Neal R. SwerdlowMing T. Tsuang, Bruce I. Turetsky, Debby W. Tsuang

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

The antisaccade task is a promising schizophrenia endophenotype; it is stable over time and reflects neurophysiological deficits present in both schizophrenia subjects and their first-degree relatives. Meaningful genetic research requires large sample sizes that are best ascertained using multi-site study designs. To establish the criterion validity of the antisaccade task in a multi-site design, the Consortium on the Genetics of Schizophrenia (COGS) examined whether seven sites could detect previously reported antisaccade deficits in schizophrenia subjects. Investigators presented 3 blocks of 20 antisaccade stimuli to 143 schizophrenia subjects and 195 comparison subjects. Frequent collaborator communication, standardized training, and ongoing quality assurance optimized testing uniformity. Data were discarded from only 1.2% of subjects due to poor quality, reflecting the high fidelity of data collection and scoring methods. All sites detected a significant difference in the proportion of correct antisaccades between schizophrenia and comparison subjects (p < .02 at all sites); group differences in gain and latency were less robust. Regression analyses to adjust for the effects of group, site, age, gender, smoking, and parental education on the proportion of correct antisaccades revealed a significant effect of group, site, and age but no effect of gender, smoking, or parental education, and no group-by-site interactions. Intraclass correlations between proportion of correct antisaccades across the blocks of stimuli ranged from 0.87 to 0.93, demonstrating good within-session reliability at sites. These results confirm previous findings of antisaccade deficits in schizophrenia subjects and support the use of the antisaccade task as a potential schizophrenia endophenotype in multi-site genetic studies.

Original language	English
Pages (from-to)	320-329
Number of pages	10
Journal	Schizophrenia Research
Volume	89
Issue number	1-3
DOIs	https://doi.org/10.1016/j.schres.2006.08.010
State	Published - Jan 2007
Externally published	Yes

Bibliographical note

Funding Information:
The authors wish to thank all of the participants and support staff that made this study possible. The authors are especially grateful to Andrew C. David for his editorial assistance. This study was supported by NIMH grants R01 MH65571, R01 MH65588, R01 MH65562, R01 MH65707, R01 MH65554, R01 MH65578, and R01 MH65558.

Funding

The authors wish to thank all of the participants and support staff that made this study possible. The authors are especially grateful to Andrew C. David for his editorial assistance. This study was supported by NIMH grants R01 MH65571, R01 MH65588, R01 MH65562, R01 MH65707, R01 MH65554, R01 MH65578, and R01 MH65558.

Funders	Funder number
National Institute of Mental Health	R01MH065558, R01 MH65707, R01 MH65562, R01 MH65571, R01 MH65578, R01 MH65588, R01 MH65554

Keywords

Antisaccade
Endophenotype
Oculomotor
Schizophrenia
Validity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.schres.2006.08.010

Cite this

Radant, A. D., Dobie, D. J., Calkins, M. E., Olincy, A., Braff, D. L., Cadenhead, K. S., Freedman, R., Green, M. F., Greenwood, T. A., Gur, R. E., Light, G. A., Meichle, S. P., Mintz, J., Nuechterlein, K. H., Schork, N. J., Seidman, L. J., Siever, L. J., Silverman, J. M., Stone, W. S., ... Tsuang, D. W. (2007). Successful multi-site measurement of antisaccade performance deficits in schizophrenia. Schizophrenia Research, 89(1-3), 320-329. https://doi.org/10.1016/j.schres.2006.08.010

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abstract = "The antisaccade task is a promising schizophrenia endophenotype; it is stable over time and reflects neurophysiological deficits present in both schizophrenia subjects and their first-degree relatives. Meaningful genetic research requires large sample sizes that are best ascertained using multi-site study designs. To establish the criterion validity of the antisaccade task in a multi-site design, the Consortium on the Genetics of Schizophrenia (COGS) examined whether seven sites could detect previously reported antisaccade deficits in schizophrenia subjects. Investigators presented 3 blocks of 20 antisaccade stimuli to 143 schizophrenia subjects and 195 comparison subjects. Frequent collaborator communication, standardized training, and ongoing quality assurance optimized testing uniformity. Data were discarded from only 1.2% of subjects due to poor quality, reflecting the high fidelity of data collection and scoring methods. All sites detected a significant difference in the proportion of correct antisaccades between schizophrenia and comparison subjects (p < .02 at all sites); group differences in gain and latency were less robust. Regression analyses to adjust for the effects of group, site, age, gender, smoking, and parental education on the proportion of correct antisaccades revealed a significant effect of group, site, and age but no effect of gender, smoking, or parental education, and no group-by-site interactions. Intraclass correlations between proportion of correct antisaccades across the blocks of stimuli ranged from 0.87 to 0.93, demonstrating good within-session reliability at sites. These results confirm previous findings of antisaccade deficits in schizophrenia subjects and support the use of the antisaccade task as a potential schizophrenia endophenotype in multi-site genetic studies.",

keywords = "Antisaccade, Endophenotype, Oculomotor, Schizophrenia, Validity",

author = "Radant, {Allen D.} and Dobie, {Dorcas J.} and Calkins, {Monica E.} and Ann Olincy and Braff, {David L.} and Cadenhead, {Kristin S.} and Robert Freedman and Green, {Michael F.} and Greenwood, {Tiffany A.} and Gur, {Raquel E.} and Light, {Gregory A.} and Meichle, {Sean P.} and Jim Mintz and Nuechterlein, {Keith H.} and Schork, {Nicholas J.} and Seidman, {Larry J.} and Siever, {Larry J.} and Silverman, {Jeremy M.} and Stone, {William S.} and Swerdlow, {Neal R.} and Tsuang, {Ming T.} and Turetsky, {Bruce I.} and Tsuang, {Debby W.}",

note = "Funding Information: The authors wish to thank all of the participants and support staff that made this study possible. The authors are especially grateful to Andrew C. David for his editorial assistance. This study was supported by NIMH grants R01 MH65571, R01 MH65588, R01 MH65562, R01 MH65707, R01 MH65554, R01 MH65578, and R01 MH65558. ",

year = "2007",

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doi = "10.1016/j.schres.2006.08.010",

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Radant, AD, Dobie, DJ, Calkins, ME, Olincy, A, Braff, DL, Cadenhead, KS, Freedman, R, Green, MF, Greenwood, TA, Gur, RE, Light, GA, Meichle, SP, Mintz, J, Nuechterlein, KH, Schork, NJ, Seidman, LJ, Siever, LJ, Silverman, JM, Stone, WS, Swerdlow, NR, Tsuang, MT, Turetsky, BI & Tsuang, DW 2007, 'Successful multi-site measurement of antisaccade performance deficits in schizophrenia', Schizophrenia Research, vol. 89, no. 1-3, pp. 320-329. https://doi.org/10.1016/j.schres.2006.08.010

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AU - Dobie, Dorcas J.

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AU - Braff, David L.

AU - Cadenhead, Kristin S.

AU - Freedman, Robert

AU - Green, Michael F.

AU - Greenwood, Tiffany A.

AU - Gur, Raquel E.

AU - Light, Gregory A.

AU - Meichle, Sean P.

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AU - Nuechterlein, Keith H.

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AU - Tsuang, Ming T.

AU - Turetsky, Bruce I.

AU - Tsuang, Debby W.

N1 - Funding Information: The authors wish to thank all of the participants and support staff that made this study possible. The authors are especially grateful to Andrew C. David for his editorial assistance. This study was supported by NIMH grants R01 MH65571, R01 MH65588, R01 MH65562, R01 MH65707, R01 MH65554, R01 MH65578, and R01 MH65558.

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N2 - The antisaccade task is a promising schizophrenia endophenotype; it is stable over time and reflects neurophysiological deficits present in both schizophrenia subjects and their first-degree relatives. Meaningful genetic research requires large sample sizes that are best ascertained using multi-site study designs. To establish the criterion validity of the antisaccade task in a multi-site design, the Consortium on the Genetics of Schizophrenia (COGS) examined whether seven sites could detect previously reported antisaccade deficits in schizophrenia subjects. Investigators presented 3 blocks of 20 antisaccade stimuli to 143 schizophrenia subjects and 195 comparison subjects. Frequent collaborator communication, standardized training, and ongoing quality assurance optimized testing uniformity. Data were discarded from only 1.2% of subjects due to poor quality, reflecting the high fidelity of data collection and scoring methods. All sites detected a significant difference in the proportion of correct antisaccades between schizophrenia and comparison subjects (p < .02 at all sites); group differences in gain and latency were less robust. Regression analyses to adjust for the effects of group, site, age, gender, smoking, and parental education on the proportion of correct antisaccades revealed a significant effect of group, site, and age but no effect of gender, smoking, or parental education, and no group-by-site interactions. Intraclass correlations between proportion of correct antisaccades across the blocks of stimuli ranged from 0.87 to 0.93, demonstrating good within-session reliability at sites. These results confirm previous findings of antisaccade deficits in schizophrenia subjects and support the use of the antisaccade task as a potential schizophrenia endophenotype in multi-site genetic studies.

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KW - Endophenotype

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KW - Schizophrenia

KW - Validity

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Successful multi-site measurement of antisaccade performance deficits in schizophrenia

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

Access to Document

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