TY - GEN
T1 - Studies on the effects of titanium and cobalt-chromium-alloys on angiogenesis in vitro
AU - Peters, K.
AU - Stenzel, F.
AU - Eisenbarth, E.
AU - Velten, D.
AU - Unger, R. E.
AU - Breme, J.
AU - Ziegler, G.
AU - Kirkpatrick, C. J.
PY - 2004
Y1 - 2004
N2 - The integrity of the endothelial layer, the functional aspect of angiogenesis and the expression of hypoxia-inducible factor-1α were investigated in vivo. Human dermal microvascular endothelial cells (HDMEC) were cultured. Cells were fixed with paraformaldehyde and stained for F-actin platelet endothelial cell adhesion molecule 1/PECAM-1, HIF-1α, and nuclei. Endothelial cells seeded on CoCr-alloys exhibited a proinflammatory phenotype. Also, the divergent distribution of HIF-1α indicated additional mechanism in angiogenic impairment.
AB - The integrity of the endothelial layer, the functional aspect of angiogenesis and the expression of hypoxia-inducible factor-1α were investigated in vivo. Human dermal microvascular endothelial cells (HDMEC) were cultured. Cells were fixed with paraformaldehyde and stained for F-actin platelet endothelial cell adhesion molecule 1/PECAM-1, HIF-1α, and nuclei. Endothelial cells seeded on CoCr-alloys exhibited a proinflammatory phenotype. Also, the divergent distribution of HIF-1α indicated additional mechanism in angiogenic impairment.
UR - https://www.scopus.com/pages/publications/13844298159
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AN - SCOPUS:13844298159
SN - 1877040193
SN - 9781877040191
T3 - Transactions - 7th World Biomaterials Congress
SP - 679
BT - Transactions - 7th World Biomaterials Congress
T2 - Transactions - 7th World Biomaterials Congress
Y2 - 17 May 2004 through 21 May 2004
ER -