Studies on the effects of titanium and cobalt-chromium-alloys on angiogenesis in vitro

K. Peters, F. Stenzel, E. Eisenbarth, D. Velten, R. E. Unger, J. Breme, G. Ziegler, C. J. Kirkpatrick

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


The integrity of the endothelial layer, the functional aspect of angiogenesis and the expression of hypoxia-inducible factor-1α were investigated in vivo. Human dermal microvascular endothelial cells (HDMEC) were cultured. Cells were fixed with paraformaldehyde and stained for F-actin platelet endothelial cell adhesion molecule 1/PECAM-1, HIF-1α, and nuclei. Endothelial cells seeded on CoCr-alloys exhibited a proinflammatory phenotype. Also, the divergent distribution of HIF-1α indicated additional mechanism in angiogenic impairment.

Original languageEnglish
Title of host publicationTransactions - 7th World Biomaterials Congress
Number of pages1
StatePublished - 2004
Externally publishedYes
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: 17 May 200421 May 2004

Publication series

NameTransactions - 7th World Biomaterials Congress


ConferenceTransactions - 7th World Biomaterials Congress


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