Studies in sugar chemistry VII. Glucuronides of podophyllum derivatives

Abraham Nudelman, Margaretta Ruse, Hugo E. Gottlieb, Craig Fairchild

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The antitumor activities of several glucuronide methyl esters of podophyllum derivatives were tested in vitro against two human tumor cell lines and their drug resistant sublines. The most active compound studied was methyl (4'-carbobenzoxy-4'-demethyl- epipodophyllotoxin-D-glucopyranoside)uronate 19. Compound 19 was as potent in a colon carcinoma model and was twice as potent in a lung carcinoma model as etoposide 6. In vivo, however, in a mouse leukemia P388 model, it had only marginal activity, with a maximum T/C% value of 125 at 37 mg/kg (iv).

Original languageEnglish
Pages (from-to)285-289
Number of pages5
JournalArchiv der Pharmazie
Volume330
Issue number9-10
DOIs
StatePublished - Oct 1997

Keywords

  • Antitumor
  • Glucuronides
  • Podophyllotoxins

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