Structures of the lectins from Pseudomonas aeruginosa: Insights into the molecular basis for host glycan recognition

Anne Imberty, Michaela Wimmerová, Edward P. Mitchell, Nechama Gilboa-Garber

Research output: Contribution to journalShort surveypeer-review

248 Scopus citations

Abstract

The opportunistic human pathogen Pseudomonas aeruginosa produces two lectins in close association with virulence factors: PA-IL and PA-IIL, which bind to galactose- and fucose/mannose-containing glycoconjugates, respectively. We review here the structural aspects of these lectins relative to their putative roles in host recognition, cell surface adhesion and biofilm formation.

Original languageEnglish
Pages (from-to)221-228
Number of pages8
JournalMicrobes and Infection
Volume6
Issue number2
DOIs
StatePublished - Feb 2004

Bibliographical note

Funding Information:
We thank Dr. Remy Loris (Vrije Universiteit Brussel, Belgium) for early access to several crystal structures and Prof. Philippe Roussel (Lille, France) for helpful discussion. Travel and visits between NCBR and CERMAV are supported by a BARRANDE exchange program. M.W.’s stay in Grenoble was supported by the French Ministry of Education and Research program for inviting scientists, and partial financial support is acknowledged from the Ministry of Education of the Czech Republic by grant No. LN00A016. N.G.G. acknowledges support from Bar-Ilan University and Israel Government Estate Property Funds, and A.I. acknowledges financial support from the French Research Minister’s Program, ACI Microbiologie and from Vaincre la Mucoviscidose.

Funding

We thank Dr. Remy Loris (Vrije Universiteit Brussel, Belgium) for early access to several crystal structures and Prof. Philippe Roussel (Lille, France) for helpful discussion. Travel and visits between NCBR and CERMAV are supported by a BARRANDE exchange program. M.W.’s stay in Grenoble was supported by the French Ministry of Education and Research program for inviting scientists, and partial financial support is acknowledged from the Ministry of Education of the Czech Republic by grant No. LN00A016. N.G.G. acknowledges support from Bar-Ilan University and Israel Government Estate Property Funds, and A.I. acknowledges financial support from the French Research Minister’s Program, ACI Microbiologie and from Vaincre la Mucoviscidose.

FundersFunder number
ACI Microbiologie
French Ministry of Education and Research program for inviting scientists
French Research Minister’s Program
Ministerstvo Školství, Mládeže a TělovýchovyLN00A016
Bar-Ilan University
Association Vaincre la Mucoviscidose

    Keywords

    • Lectins
    • Oligosaccharides
    • PA-IIL
    • PA-IL
    • Pseudomonas aeruginosa

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