Structures of the lectins from Pseudomonas aeruginosa: Insights into the molecular basis for host glycan recognition

Anne Imberty; Michaela Wimmerová; Edward P. Mitchell; Nechama Gilboa-Garber

doi:10.1016/j.micinf.2003.10.016

Structures of the lectins from Pseudomonas aeruginosa: Insights into the molecular basis for host glycan recognition

Anne Imberty, Michaela Wimmerová, Edward P. Mitchell, Nechama Gilboa-Garber

The Mina and Everard Goodman Faculty of Life Sciences - at Bar-Ilan University

Research output: Contribution to journal › Short survey › peer-review

254 Scopus citations

Abstract

The opportunistic human pathogen Pseudomonas aeruginosa produces two lectins in close association with virulence factors: PA-IL and PA-IIL, which bind to galactose- and fucose/mannose-containing glycoconjugates, respectively. We review here the structural aspects of these lectins relative to their putative roles in host recognition, cell surface adhesion and biofilm formation.

Original language	English
Pages (from-to)	221-228
Number of pages	8
Journal	Microbes and Infection
Volume	6
Issue number	2
DOIs	https://doi.org/10.1016/j.micinf.2003.10.016
State	Published - Feb 2004

Bibliographical note

Funding Information:
We thank Dr. Remy Loris (Vrije Universiteit Brussel, Belgium) for early access to several crystal structures and Prof. Philippe Roussel (Lille, France) for helpful discussion. Travel and visits between NCBR and CERMAV are supported by a BARRANDE exchange program. M.W.’s stay in Grenoble was supported by the French Ministry of Education and Research program for inviting scientists, and partial financial support is acknowledged from the Ministry of Education of the Czech Republic by grant No. LN00A016. N.G.G. acknowledges support from Bar-Ilan University and Israel Government Estate Property Funds, and A.I. acknowledges financial support from the French Research Minister’s Program, ACI Microbiologie and from Vaincre la Mucoviscidose.

Funding

We thank Dr. Remy Loris (Vrije Universiteit Brussel, Belgium) for early access to several crystal structures and Prof. Philippe Roussel (Lille, France) for helpful discussion. Travel and visits between NCBR and CERMAV are supported by a BARRANDE exchange program. M.W.’s stay in Grenoble was supported by the French Ministry of Education and Research program for inviting scientists, and partial financial support is acknowledged from the Ministry of Education of the Czech Republic by grant No. LN00A016. N.G.G. acknowledges support from Bar-Ilan University and Israel Government Estate Property Funds, and A.I. acknowledges financial support from the French Research Minister’s Program, ACI Microbiologie and from Vaincre la Mucoviscidose.

Funders	Funder number
ACI Microbiologie
French Ministry of Education and Research program for inviting scientists
French Research Minister’s Program
Ministerstvo Školství, Mládeže a Tělovýchovy	LN00A016
Bar-Ilan University
Association Vaincre la Mucoviscidose

Keywords

Lectins
Oligosaccharides
PA-IIL
PA-IL
Pseudomonas aeruginosa

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.micinf.2003.10.016

Cite this

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title = "Structures of the lectins from Pseudomonas aeruginosa: Insights into the molecular basis for host glycan recognition",

abstract = "The opportunistic human pathogen Pseudomonas aeruginosa produces two lectins in close association with virulence factors: PA-IL and PA-IIL, which bind to galactose- and fucose/mannose-containing glycoconjugates, respectively. We review here the structural aspects of these lectins relative to their putative roles in host recognition, cell surface adhesion and biofilm formation.",

keywords = "Lectins, Oligosaccharides, PA-IIL, PA-IL, Pseudomonas aeruginosa",

author = "Anne Imberty and Michaela Wimmerov{\'a} and Mitchell, {Edward P.} and Nechama Gilboa-Garber",

note = "Funding Information: We thank Dr. Remy Loris (Vrije Universiteit Brussel, Belgium) for early access to several crystal structures and Prof. Philippe Roussel (Lille, France) for helpful discussion. Travel and visits between NCBR and CERMAV are supported by a BARRANDE exchange program. M.W.{\textquoteright}s stay in Grenoble was supported by the French Ministry of Education and Research program for inviting scientists, and partial financial support is acknowledged from the Ministry of Education of the Czech Republic by grant No. LN00A016. N.G.G. acknowledges support from Bar-Ilan University and Israel Government Estate Property Funds, and A.I. acknowledges financial support from the French Research Minister{\textquoteright}s Program, ACI Microbiologie and from Vaincre la Mucoviscidose.",

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doi = "10.1016/j.micinf.2003.10.016",

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AU - Wimmerová, Michaela

AU - Mitchell, Edward P.

AU - Gilboa-Garber, Nechama

N1 - Funding Information: We thank Dr. Remy Loris (Vrije Universiteit Brussel, Belgium) for early access to several crystal structures and Prof. Philippe Roussel (Lille, France) for helpful discussion. Travel and visits between NCBR and CERMAV are supported by a BARRANDE exchange program. M.W.’s stay in Grenoble was supported by the French Ministry of Education and Research program for inviting scientists, and partial financial support is acknowledged from the Ministry of Education of the Czech Republic by grant No. LN00A016. N.G.G. acknowledges support from Bar-Ilan University and Israel Government Estate Property Funds, and A.I. acknowledges financial support from the French Research Minister’s Program, ACI Microbiologie and from Vaincre la Mucoviscidose.

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N2 - The opportunistic human pathogen Pseudomonas aeruginosa produces two lectins in close association with virulence factors: PA-IL and PA-IIL, which bind to galactose- and fucose/mannose-containing glycoconjugates, respectively. We review here the structural aspects of these lectins relative to their putative roles in host recognition, cell surface adhesion and biofilm formation.

AB - The opportunistic human pathogen Pseudomonas aeruginosa produces two lectins in close association with virulence factors: PA-IL and PA-IIL, which bind to galactose- and fucose/mannose-containing glycoconjugates, respectively. We review here the structural aspects of these lectins relative to their putative roles in host recognition, cell surface adhesion and biofilm formation.

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Structures of the lectins from Pseudomonas aeruginosa: Insights into the molecular basis for host glycan recognition

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

Access to Document

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