Structure, Function and Pharmacology of SLC7 Family Members and Homologues

Jean Marc Jeckelmann, Jonas Zaugg, Veronika Morozova, Jennifer Müller, Satish Kantipudi, Mariana Schroeder, Julien Graff, Christiane Albrecht, Karl Heinz Altmann, Jürg Gertsch, Dimitrios Fotiadis

Research output: Contribution to journalArticlepeer-review

Abstract

Amino acids are essential components of all living cells serving as building blocks of proteins, as energy source, and as precursors of metabolites and signaling molecules. Amino acid transporters are membrane proteins that mediate the transfer of amino acids across the plasma membrane, and between compartments in cells, different cells and organs. The absence, overexpression or malfunction of specific amino acid transporters have been associated with human disease. One of the projects within the Swiss National Centre of Competence in Research (NCCR) TransCure was directed at SLC7 family amino acid transporters, with a particular focus on the heteromeric amino acid transporters 4F2hc-LAT1 (SLC3A2-SLC7A5) and 4F2hc-LAT2 (SLC3A2-SLC7A8), and the bacterial homologue AdiC. The project addressed questions of basic research (function and structure), pharmacology (identification of potent inhibitors and activators), and pre-clinical medicine (e.g., physiological role in the placenta) and disease models (e.g., tumor progression) of specific SLC7 family amino acid transporters. This review presents, summarizes and discusses selected main results obtained in this NCCR TransCure project.

Original languageEnglish
Pages (from-to)1011-1018
Number of pages8
JournalChimia
Volume76
Issue number12
DOIs
StatePublished - Dec 2022
Externally publishedYes

Bibliographical note

Publisher Copyright:
© J.-M. Jeckelmann et al.

Keywords

  • Amino acid transporter
  • Inhibitor
  • LAT1
  • LAT2
  • SLC7

Fingerprint

Dive into the research topics of 'Structure, Function and Pharmacology of SLC7 Family Members and Homologues'. Together they form a unique fingerprint.

Cite this