Structure and ligand-binding site characteristics of the human P2Y ₁₁ nucleotide receptor deduced from computational modelling and mutational analysis

Keyphrases

• Computational Modeling 100%
• Phosphate 100%
• Nucleotide Receptors 100%
• Mutational Analysis 100%
• P2Y11 Receptor 100%
• Ligand Binding Site 100%
• P2Y11 100%
• Site Characteristics 100%
• R-model 100%
• Modeling Analysis 100%
• Hydrogen Bonds (H-bonds) 100%
• Order of Magnitude 50%
• High Activity 50%
• Ionic Interaction 50%
• G Protein-coupled Receptor 50%
• Triphosphate 50%
• P2Y1 50%
• Homology Modeling 50%
• Hydrophobic Pocket 50%
• Three-order 50%
• Drug Target 50%
• Carbonyl 50%
• Ligand Recognition 50%
• Model Complexity 50%
• Rhodopsin 50%
• Inactivity 50%
• Enrichment Factor 50%
• Molecular Dynamics Calculations 50%
• Molecular Switches 50%
• Recognition Mode 50%
• Virtual Screening 50%

Biochemistry, Genetics and Molecular Biology

• Ligand Binding 100%
• Binding Site 100%
• Adenosine Triphosphate 100%
• Eicosanoid Receptor 100%
• Adenine 22%
• Dynamics 11%
• Screening 11%
• DNA Template 11%
• G Protein Coupled Receptor 11%
• Cyclic Adenosine Monophosphate 11%
• Proteorhodopsin 11%
• Rhodopsin 11%