Structural specificity of serotonin effect on human erythrocyte fragility

Nechama Gilboa-Garber, Rivka Kirstein-Segal

    Research output: Contribution to journalArticlepeer-review

    2 Scopus citations


    Serotonin, a neurotransmitter and vasoconstrictor, affects various cell properties. We have analyzed the importance of its structural components for its extensive effect on human erythrocyte fragility, using its O- and N- linked derivatives and related compounds. The results presented in this communication indicate that the amino group, free of adjacent negative charges, and the hydroxyl group are indispensable for the serotonin-induced increase in red blood cell fragility.

    Original languageEnglish
    Pages (from-to)283-285
    Number of pages3
    JournalMolecular Genetics and Metabolism
    Issue number4
    StatePublished - Aug 1998


    • Cell damage
    • Erythrocyte fragility
    • Histamine
    • Monoamines
    • Serotonin (5-hydroxytryptamine)


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