TY - JOUR
T1 - Structural specificity of serotonin effect on human erythrocyte fragility
AU - Gilboa-Garber, Nechama
AU - Kirstein-Segal, Rivka
PY - 1998/8
Y1 - 1998/8
N2 - Serotonin, a neurotransmitter and vasoconstrictor, affects various cell properties. We have analyzed the importance of its structural components for its extensive effect on human erythrocyte fragility, using its O- and N- linked derivatives and related compounds. The results presented in this communication indicate that the amino group, free of adjacent negative charges, and the hydroxyl group are indispensable for the serotonin-induced increase in red blood cell fragility.
AB - Serotonin, a neurotransmitter and vasoconstrictor, affects various cell properties. We have analyzed the importance of its structural components for its extensive effect on human erythrocyte fragility, using its O- and N- linked derivatives and related compounds. The results presented in this communication indicate that the amino group, free of adjacent negative charges, and the hydroxyl group are indispensable for the serotonin-induced increase in red blood cell fragility.
KW - Cell damage
KW - Erythrocyte fragility
KW - Histamine
KW - Monoamines
KW - Serotonin (5-hydroxytryptamine)
UR - http://www.scopus.com/inward/record.url?scp=0031688458&partnerID=8YFLogxK
U2 - 10.1006/mgme.1998.2703
DO - 10.1006/mgme.1998.2703
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C2 - 9758719
AN - SCOPUS:0031688458
SN - 1096-7192
VL - 64
SP - 283
EP - 285
JO - Molecular Genetics and Metabolism
JF - Molecular Genetics and Metabolism
IS - 4
ER -