Abstract
The review of Progress in Nuclear Magnetic Resonance Spectroscopy demonstrated the application of the slowly relaxing local structure (SRLS) approach in structural dynamics of bio-macromolecules by NMR. SRLS was demonstrated to be a stochastic two-body coupled-rotator diffusive approach, having the potential to be generalized to three or more bodies that were coupled, along with the inclusion of inertial effects in these motions. The review offered the concepts that emphasized SRLS as an alternative to the model-free point-of-view approach, while describing and demonstrating the way SRLS was to be implemented in a practical manner. application of SRLS and model-free (MF) to a large number of data sets revealed that MF was frequently a force-fitting to the experimental data and that SRLS and MF analyses were quantitative in nature.
Original language | English |
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Pages (from-to) | 360-405 |
Number of pages | 46 |
Journal | Progress in Nuclear Magnetic Resonance Spectroscopy |
Volume | 56 |
Issue number | 4 |
DOIs | |
State | Published - May 2010 |
Bibliographical note
Funding Information:This work was supported by the Israel Science Foundation (Grant No. 347/07 to E.M.), the Binational Science Foundation (Grant No. 2006050 to E.M. and J.H.F.), the German-Israeli Science Foundation for Scientific Research and Development to E.M. and Christian Griesinger (Grant No. 928-190.0/2006 ), and the Damadian Center for Magnetic Resonance at Bar-Ilan University , Israel. This work was also supported by the National Center for Research Resources of the National Institutes of Health (Grant No. P41-R, R016292 to J.H.F.). A.P. acknowledges support provided by Ministero dell’Istruzione, Universita e Ricerca (MIUR) , grant PRIN 2006 ( 2006033728 ), and by the University of Padova , grant “Progetto Strategico” HELIOS 2009.
Funding
This work was supported by the Israel Science Foundation (Grant No. 347/07 to E.M.), the Binational Science Foundation (Grant No. 2006050 to E.M. and J.H.F.), the German-Israeli Science Foundation for Scientific Research and Development to E.M. and Christian Griesinger (Grant No. 928-190.0/2006 ), and the Damadian Center for Magnetic Resonance at Bar-Ilan University , Israel. This work was also supported by the National Center for Research Resources of the National Institutes of Health (Grant No. P41-R, R016292 to J.H.F.). A.P. acknowledges support provided by Ministero dell’Istruzione, Universita e Ricerca (MIUR) , grant PRIN 2006 ( 2006033728 ), and by the University of Padova , grant “Progetto Strategico” HELIOS 2009.
Funders | Funder number |
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Ministero dell’Istruzione, Universita e Ricerca | |
National Institutes of Health | |
National Center for Research Resources | P41RR016292 |
German-Israeli Foundation for Scientific Research and Development | 928-190.0/2006 |
United States-Israel Binational Science Foundation | 2006050 |
Ministero dellâIstruzione, dellâUniversità e della Ricerca | PRIN 2006, 2006033728 |
Università degli Studi di Padova | |
Israel Science Foundation | 347/07 |
Keywords
- NMR spin relaxation
- Protein dynamics
- SRLS
- Stochastic motional models