Structural and Mechanistic Aspects of 3C Proteases from the Picornavirus Family

Dorit Arad, Racheli Kreisberg, Michael Shokhen

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Picornavirus 3C proteases are prime targets for rational drug design. This viral protease appears in a large number of viruses from the Picornavirus family that cause serious disease syndromes, and it has an important role in the life cycle of the virus, processing the translation product of the Picornavirus genome by progressive co- and posttranslational cleavages. It is, therefore, important to gain structural and mechanistic information about this family of enzymes. We concentrate in this paper on the specific features of the 3C; particularly, we are trying to show that the 3C constitute a new family to enzymes which is neither a serine- nor a cysteine-type protease. General basic theory on the behavior of sulfur nucleophile vs the behavior of oxygen nucleophile regarding the nucleophilic attack on carbonyl compounds and the possible determinants in the structure of 3C viral proteases of rhinovirus 1A are being discussed.

Original languageEnglish
Pages (from-to)345-349
Number of pages5
JournalJournal of Chemical Information and Computer Sciences
Issue number3
StatePublished - 1993
Externally publishedYes


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