TY - JOUR
T1 - Strontium hexaferrite nanomagnets suspended in a cosmetic preparation
T2 - a convenient tool to evaluate the biological effects of surface magnetism on human skin
AU - Zioni, T.
AU - Perkas, N.
AU - Wolfus, Y.
AU - Soroka, Y.
AU - Popov, I.
AU - Oron, M.
AU - Perelshtein, I.
AU - Bruckental, Y.
AU - Brégégère, F. M.
AU - Ma'or, Z.
AU - Gedanken, A.
AU - Yeshurun, Y.
AU - Neuman, R.
AU - Milner, Y.
PY - 2010/8
Y1 - 2010/8
N2 - Background/purpose: Magnetic therapy has been popular for ages, but its therapeutic abilities remain to be demonstrated. We aimed to develop a homogeneous, stable dispersion of magnetic nanoparticles in a skin-care preparation, as a tool to analyze the biological and physiological effects of superficial magnetism in skin. Methods: SrFe12O19 nanoparticles were generated by ultrasound, dispersed in glycerol, stabilized in Dermud™ cream and permanently magnetized. The magnetic cream was applied on the epidermis of human skin organ cultures. The effects on UV-induced cell toxicity, apoptosis and inflammatory cytokine expression were analyzed. A clinical test was performed to check skin moisturization. Results: Nanomagnets were found to be homogenously and stably dispersed. After magnetization, the preparation generated a magnetic field of 1-2 G. Upon cream application, no cytotoxicity and no impairment of cellular vitality were found after 24 and 48 h, respectively. The anti-apoptotic and anti-inflammatory properties of Dermud™ were not modified, but its long-term effect on moisturization in vivo was slightly increased. Conclusion: Nanomagnetic Dermud™ cream can be used as a tool to analyze the biological effects of nanomagnets dispersed on the skin surface at the cellular and molecular levels, thus allowing to explore the possible therapeutic uses of superficial magnetism for skin care.
AB - Background/purpose: Magnetic therapy has been popular for ages, but its therapeutic abilities remain to be demonstrated. We aimed to develop a homogeneous, stable dispersion of magnetic nanoparticles in a skin-care preparation, as a tool to analyze the biological and physiological effects of superficial magnetism in skin. Methods: SrFe12O19 nanoparticles were generated by ultrasound, dispersed in glycerol, stabilized in Dermud™ cream and permanently magnetized. The magnetic cream was applied on the epidermis of human skin organ cultures. The effects on UV-induced cell toxicity, apoptosis and inflammatory cytokine expression were analyzed. A clinical test was performed to check skin moisturization. Results: Nanomagnets were found to be homogenously and stably dispersed. After magnetization, the preparation generated a magnetic field of 1-2 G. Upon cream application, no cytotoxicity and no impairment of cellular vitality were found after 24 and 48 h, respectively. The anti-apoptotic and anti-inflammatory properties of Dermud™ were not modified, but its long-term effect on moisturization in vivo was slightly increased. Conclusion: Nanomagnetic Dermud™ cream can be used as a tool to analyze the biological effects of nanomagnets dispersed on the skin surface at the cellular and molecular levels, thus allowing to explore the possible therapeutic uses of superficial magnetism for skin care.
KW - Inflammatory cytokines
KW - Magnetotherapy
KW - Nanoparticles
KW - Skin care
KW - UV damage
UR - http://www.scopus.com/inward/record.url?scp=77955154716&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0846.2010.00435.x
DO - 10.1111/j.1600-0846.2010.00435.x
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C2 - 20637001
AN - SCOPUS:77955154716
SN - 0909-752X
VL - 16
SP - 316
EP - 324
JO - Skin Research and Technology
JF - Skin Research and Technology
IS - 3
ER -