Striosomes Mediate Value-Based Learning Vulnerable in Age and a Huntington's Disease Model

Alexander Friedman, Emily Hueske, Sabrina M. Drammis, Sebastian E. Toro Arana, Erik D. Nelson, Cody W. Carter, Sebastien Delcasso, Raimundo X. Rodriguez, Hope Lutwak, Kaden S. DiMarco, Qingyang Zhang, Lara I. Rakocevic, Dan Hu, Joshua K. Xiong, Jiajia Zhao, Leif G. Gibb, Tomoko Yoshida, Cody A. Siciliano, Thomas J. Diefenbach, Charu RamakrishnanKarl Deisseroth, Ann M. Graybiel

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Friedman et al. find that specialized regions of the striatum, a key part of the brain's movement and motivation control system, are essential for learning about the values of good and bad outcomes of decisions. The learning signals in striosomes scale according to subjective value and are vulnerable to decline with aging and in neurodegenerative disorders.

Original languageEnglish
Pages (from-to)918-934.e49
JournalCell
Volume183
Issue number4
DOIs
StatePublished - 12 Nov 2020
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2020 Elsevier Inc.

Funding

The authors thank Dr. Nancy Lynch, Dr. Ken-ichi Amemori, Josh Wardell, Dr. Dan Gibson, Dr. Akiko Wagatsuma, Dr. Teruhiro Okuyama, Dr. Min Jung Kim, and Henry Hall for critical help with methodological development; Dr. Yasuo Kubota for help with manuscript preparation; and undergraduate students Juan D. Fajardo, Kian Hutt Vater, Quilee Simeon, Shirley Wu, Isabella Guerrero, Timothy F. Truong, Cassidy Nairns, and Grace Lin for experimental and data analysis work. This research was funded by the CHDI Foundation ( A-5552 ), the Saks Kavanaugh Foundation , NIH/NIMH ( R01 MH060379 and P50 MH119467 ), the Nancy Lurie Marks Family Foundation , the Bachmann-Strauss Dystonia & Parkinson Foundation , the William N. & Bernice E. Bumpus Foundation (RRDA Pilot: 2013.1 ), Simons Center for the Social Brain, Kristin R. Pressman and Jessica J. Pourian ‘13 Fund, Michael D. Stiefel , and Robert Buxton . The authors thank Dr. Nancy Lynch, Dr. Ken-ichi Amemori, Josh Wardell, Dr. Dan Gibson, Dr. Akiko Wagatsuma, Dr. Teruhiro Okuyama, Dr. Min Jung Kim, and Henry Hall for critical help with methodological development; Dr. Yasuo Kubota for help with manuscript preparation; and undergraduate students Juan D. Fajardo, Kian Hutt Vater, Quilee Simeon, Shirley Wu, Isabella Guerrero, Timothy F. Truong, Cassidy Nairns, and Grace Lin for experimental and data analysis work. This research was funded by the CHDI Foundation (A-5552), the Saks Kavanaugh Foundation, NIH/NIMH (R01 MH060379 and P50 MH119467), the Nancy Lurie Marks Family Foundation, the Bachmann-Strauss Dystonia & Parkinson Foundation, the William N. & Bernice E. Bumpus Foundation (RRDA Pilot: 2013.1), Simons Center for the Social Brain, Kristin R. Pressman and Jessica J. Pourian ?13 Fund, Michael D. Stiefel, and Robert Buxton. Conceptualization, A.F. E.H. and A.M.G.; Methodology, A.F. E.H. E.D.N. C.W.C. S.D. H.L. D.H. and C.A.S.; Software, S.M.D. S.E.T.A. S.D. R.X.R. K.S.D. Q.Z. L.I.R. and J.K.X.; Validation, A.F. E.H. S.M.D. and S.E.T.A.; Formal Analysis, A.F. E.H. S.M.D. S.E.T.A. R.X.R. K.S.D. Q.Z. L.I.R. and J.Z.; Resources, L.G.G. T.J.D. C.R. and K.D.; Modeling, A.F. and S.M.D.; Investigation of Photometrics and Behavioral Data Collection, A.F. E.H. C.W.C. and D.H.; Investigation of Immunohistochemistry Staining and Imaging, A.F. E.H. E.D.N. and A.M.G.; Data Curation, S.M.D. and S.E.T.A.; Writing, A.F. E.H. E.D.N. and A.M.G.; Visual Presentation, A.F. E.H. S.M.D. S.E.T.A. E.D.N. and A.M.G.; Supervision, A.F. E.H. and A.M.G.; Project Administration, A.M.G.; Funding Acquisition, A.M.G. The authors declare no competing interests.

FundersFunder number
NIH/NIMH
Saks Kavanaugh Foundation
Simons Center for the Social Brain
William N. & Bernice E. Bumpus Foundation2013.1
National Institutes of Health
National Institute of Mental HealthP50 MH119467, R01 MH060379
National Institute on Drug AbuseR00DA045103
Bachmann-Strauss Dystonia and Parkinson Foundation
CHDI FoundationA-5552
Nancy Lurie Marks Family Foundation

    Keywords

    • VGluT1
    • approach-avoidance
    • corticostriatal
    • cost-benefit
    • decision-making
    • excitation-inhibition balance
    • motivation
    • parvalbumin interneurons
    • subjective value
    • utility

    Fingerprint

    Dive into the research topics of 'Striosomes Mediate Value-Based Learning Vulnerable in Age and a Huntington's Disease Model'. Together they form a unique fingerprint.

    Cite this