Striosomes Mediate Value-Based Learning Vulnerable in Age and a Huntington's Disease Model

Alexander Friedman; Emily Hueske; Sabrina M. Drammis; Sebastian E. Toro Arana; Erik D. Nelson; Cody W. Carter; Sebastien Delcasso; Raimundo X. Rodriguez; Hope Lutwak; Kaden S. DiMarco; Qingyang Zhang; Lara I. Rakocevic; Dan Hu; Joshua K. Xiong; Jiajia Zhao; Leif G. Gibb; Tomoko Yoshida; Cody A. Siciliano; Thomas J. Diefenbach; Charu Ramakrishnan; Karl Deisseroth; Ann M. Graybiel

doi:10.1016/j.cell.2020.09.060

Striosomes Mediate Value-Based Learning Vulnerable in Age and a Huntington's Disease Model

Alexander Friedman, Emily Hueske, Sabrina M. Drammis, Sebastian E. Toro Arana, Erik D. Nelson, Cody W. Carter, Sebastien Delcasso, Raimundo X. Rodriguez, Hope Lutwak, Kaden S. DiMarco, Qingyang Zhang, Lara I. Rakocevic, Dan Hu, Joshua K. Xiong, Jiajia Zhao, Leif G. Gibb, Tomoko Yoshida, Cody A. Siciliano, Thomas J. Diefenbach, Charu RamakrishnanKarl Deisseroth, Ann M. Graybiel

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Friedman et al. find that specialized regions of the striatum, a key part of the brain's movement and motivation control system, are essential for learning about the values of good and bad outcomes of decisions. The learning signals in striosomes scale according to subjective value and are vulnerable to decline with aging and in neurodegenerative disorders.

Original language	English
Pages (from-to)	918-934.e49
Journal	Cell
Volume	183
Issue number	4
DOIs	https://doi.org/10.1016/j.cell.2020.09.060
State	Published - 12 Nov 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020 Elsevier Inc.

Funding

The authors thank Dr. Nancy Lynch, Dr. Ken-ichi Amemori, Josh Wardell, Dr. Dan Gibson, Dr. Akiko Wagatsuma, Dr. Teruhiro Okuyama, Dr. Min Jung Kim, and Henry Hall for critical help with methodological development; Dr. Yasuo Kubota for help with manuscript preparation; and undergraduate students Juan D. Fajardo, Kian Hutt Vater, Quilee Simeon, Shirley Wu, Isabella Guerrero, Timothy F. Truong, Cassidy Nairns, and Grace Lin for experimental and data analysis work. This research was funded by the CHDI Foundation ( A-5552 ), the Saks Kavanaugh Foundation , NIH/NIMH ( R01 MH060379 and P50 MH119467 ), the Nancy Lurie Marks Family Foundation , the Bachmann-Strauss Dystonia & Parkinson Foundation , the William N. & Bernice E. Bumpus Foundation (RRDA Pilot: 2013.1 ), Simons Center for the Social Brain, Kristin R. Pressman and Jessica J. Pourian ‘13 Fund, Michael D. Stiefel , and Robert Buxton . The authors thank Dr. Nancy Lynch, Dr. Ken-ichi Amemori, Josh Wardell, Dr. Dan Gibson, Dr. Akiko Wagatsuma, Dr. Teruhiro Okuyama, Dr. Min Jung Kim, and Henry Hall for critical help with methodological development; Dr. Yasuo Kubota for help with manuscript preparation; and undergraduate students Juan D. Fajardo, Kian Hutt Vater, Quilee Simeon, Shirley Wu, Isabella Guerrero, Timothy F. Truong, Cassidy Nairns, and Grace Lin for experimental and data analysis work. This research was funded by the CHDI Foundation (A-5552), the Saks Kavanaugh Foundation, NIH/NIMH (R01 MH060379 and P50 MH119467), the Nancy Lurie Marks Family Foundation, the Bachmann-Strauss Dystonia & Parkinson Foundation, the William N. & Bernice E. Bumpus Foundation (RRDA Pilot: 2013.1), Simons Center for the Social Brain, Kristin R. Pressman and Jessica J. Pourian ?13 Fund, Michael D. Stiefel, and Robert Buxton. Conceptualization, A.F. E.H. and A.M.G.; Methodology, A.F. E.H. E.D.N. C.W.C. S.D. H.L. D.H. and C.A.S.; Software, S.M.D. S.E.T.A. S.D. R.X.R. K.S.D. Q.Z. L.I.R. and J.K.X.; Validation, A.F. E.H. S.M.D. and S.E.T.A.; Formal Analysis, A.F. E.H. S.M.D. S.E.T.A. R.X.R. K.S.D. Q.Z. L.I.R. and J.Z.; Resources, L.G.G. T.J.D. C.R. and K.D.; Modeling, A.F. and S.M.D.; Investigation of Photometrics and Behavioral Data Collection, A.F. E.H. C.W.C. and D.H.; Investigation of Immunohistochemistry Staining and Imaging, A.F. E.H. E.D.N. and A.M.G.; Data Curation, S.M.D. and S.E.T.A.; Writing, A.F. E.H. E.D.N. and A.M.G.; Visual Presentation, A.F. E.H. S.M.D. S.E.T.A. E.D.N. and A.M.G.; Supervision, A.F. E.H. and A.M.G.; Project Administration, A.M.G.; Funding Acquisition, A.M.G. The authors declare no competing interests.

Funders	Funder number
NIH/NIMH
Saks Kavanaugh Foundation
Simons Center for the Social Brain
William N. & Bernice E. Bumpus Foundation	2013.1
National Institutes of Health
National Institute of Mental Health	P50 MH119467, R01 MH060379
National Institute on Drug Abuse	R00DA045103
Bachmann-Strauss Dystonia and Parkinson Foundation
CHDI Foundation	A-5552
Nancy Lurie Marks Family Foundation

Keywords

VGluT1
approach-avoidance
corticostriatal
cost-benefit
decision-making
excitation-inhibition balance
motivation
parvalbumin interneurons
subjective value
utility

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Friedman, A., Hueske, E., Drammis, S. M., Toro Arana, S. E., Nelson, E. D., Carter, C. W., Delcasso, S., Rodriguez, R. X., Lutwak, H., DiMarco, K. S., Zhang, Q., Rakocevic, L. I., Hu, D., Xiong, J. K., Zhao, J., Gibb, L. G., Yoshida, T., Siciliano, C. A., Diefenbach, T. J., ... Graybiel, A. M. (2020). Striosomes Mediate Value-Based Learning Vulnerable in Age and a Huntington's Disease Model. Cell, 183(4), 918-934.e49. https://doi.org/10.1016/j.cell.2020.09.060

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title = "Striosomes Mediate Value-Based Learning Vulnerable in Age and a Huntington's Disease Model",

abstract = "Friedman et al. find that specialized regions of the striatum, a key part of the brain's movement and motivation control system, are essential for learning about the values of good and bad outcomes of decisions. The learning signals in striosomes scale according to subjective value and are vulnerable to decline with aging and in neurodegenerative disorders.",

keywords = "VGluT1, approach-avoidance, corticostriatal, cost-benefit, decision-making, excitation-inhibition balance, motivation, parvalbumin interneurons, subjective value, utility",

author = "Alexander Friedman and Emily Hueske and Drammis, {Sabrina M.} and {Toro Arana}, {Sebastian E.} and Nelson, {Erik D.} and Carter, {Cody W.} and Sebastien Delcasso and Rodriguez, {Raimundo X.} and Hope Lutwak and DiMarco, {Kaden S.} and Qingyang Zhang and Rakocevic, {Lara I.} and Dan Hu and Xiong, {Joshua K.} and Jiajia Zhao and Gibb, {Leif G.} and Tomoko Yoshida and Siciliano, {Cody A.} and Diefenbach, {Thomas J.} and Charu Ramakrishnan and Karl Deisseroth and Graybiel, {Ann M.}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = nov,

day = "12",

doi = "10.1016/j.cell.2020.09.060",

language = "אנגלית",

volume = "183",

pages = "918--934.e49",

journal = "Cell",

issn = "0092-8674",

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Friedman, A, Hueske, E, Drammis, SM, Toro Arana, SE, Nelson, ED, Carter, CW, Delcasso, S, Rodriguez, RX, Lutwak, H, DiMarco, KS, Zhang, Q, Rakocevic, LI, Hu, D, Xiong, JK, Zhao, J, Gibb, LG, Yoshida, T, Siciliano, CA, Diefenbach, TJ, Ramakrishnan, C, Deisseroth, K & Graybiel, AM 2020, 'Striosomes Mediate Value-Based Learning Vulnerable in Age and a Huntington's Disease Model', Cell, vol. 183, no. 4, pp. 918-934.e49. https://doi.org/10.1016/j.cell.2020.09.060

TY - JOUR

T1 - Striosomes Mediate Value-Based Learning Vulnerable in Age and a Huntington's Disease Model

AU - Friedman, Alexander

AU - Hueske, Emily

AU - Drammis, Sabrina M.

AU - Toro Arana, Sebastian E.

AU - Nelson, Erik D.

AU - Carter, Cody W.

AU - Delcasso, Sebastien

AU - Rodriguez, Raimundo X.

AU - Lutwak, Hope

AU - DiMarco, Kaden S.

AU - Zhang, Qingyang

AU - Rakocevic, Lara I.

AU - Hu, Dan

AU - Xiong, Joshua K.

AU - Zhao, Jiajia

AU - Gibb, Leif G.

AU - Yoshida, Tomoko

AU - Siciliano, Cody A.

AU - Diefenbach, Thomas J.

AU - Ramakrishnan, Charu

AU - Deisseroth, Karl

AU - Graybiel, Ann M.

PY - 2020/11/12

Y1 - 2020/11/12

N2 - Friedman et al. find that specialized regions of the striatum, a key part of the brain's movement and motivation control system, are essential for learning about the values of good and bad outcomes of decisions. The learning signals in striosomes scale according to subjective value and are vulnerable to decline with aging and in neurodegenerative disorders.

AB - Friedman et al. find that specialized regions of the striatum, a key part of the brain's movement and motivation control system, are essential for learning about the values of good and bad outcomes of decisions. The learning signals in striosomes scale according to subjective value and are vulnerable to decline with aging and in neurodegenerative disorders.

KW - VGluT1

KW - approach-avoidance

KW - corticostriatal

KW - cost-benefit

KW - decision-making

KW - excitation-inhibition balance

KW - motivation

KW - parvalbumin interneurons

KW - subjective value

KW - utility

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SN - 0092-8674

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JO - Cell

JF - Cell

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ER -

Striosomes Mediate Value-Based Learning Vulnerable in Age and a Huntington's Disease Model

Abstract

Bibliographical note

Funding

Keywords

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