Strain release is not enough

Ariel Sella, Harold Basch, Shmaryahu Hoz

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


The activation barrier for the nucleophilic attack of CN- on [1.1.1]-propellane is lowered by 60.7 kcal (compared to the strain free analog) while the total strain energy released in the reaction is only 45 kcal showing that strained molecules react faster not only because of partial strain release at the transition state.

Original languageEnglish
Pages (from-to)5573-5576
Number of pages4
JournalTetrahedron Letters
Issue number31
StatePublished - 29 Jul 1996


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