Stopping rules for clinical trials incorporating clinical opinion.

L. S. Freedman, D. Lowe, P. Macaskill

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

A method is described of eliciting a 'range of equivalence', i.e. a range of differences between two treatments over which a group of clinical trial participants would have no clear preference for either treatment. This range of equivalence is then incorporated into a formal stopping rule for the trial using an extension of the group sequential design. Tables for the implementation of the design are presented. The method is discussed in the context of other sequential-trial designs.

Original languageEnglish
Pages (from-to)575-586
Number of pages12
JournalBiometrics
Volume40
Issue number3
DOIs
StatePublished - 1984

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