Stopping rules for clinical trials

L. S. Freedman; D. Lowe; P. Macaskill

doi:10.1002/sim.4780020210

Stopping rules for clinical trials

L. S. Freedman, D. Lowe, P. Macaskill

Medical Research Council

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

We describe a new method of formulating stopping rules for clinical trials, one that incorporates opinion on what difference is clinically important. We compare the method with conventional group sequential designs and illustrate it by application to a study of Pancuronium Bromide for prevention of haemorrhage in pre‐term infants.

Original language	English
Pages (from-to)	167-174
Number of pages	8
Journal	Statistics in Medicine
Volume	2
Issue number	2
DOIs	https://doi.org/10.1002/sim.4780020210
State	Published - 1983
Externally published	Yes

Keywords

Clinical trials
Group sequential designs
Intraventricular haemorrhage
Pre‐term infants
Stopping rules

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10.1002/sim.4780020210

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abstract = "We describe a new method of formulating stopping rules for clinical trials, one that incorporates opinion on what difference is clinically important. We compare the method with conventional group sequential designs and illustrate it by application to a study of Pancuronium Bromide for prevention of haemorrhage in pre‐term infants.",

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year = "1983",

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KW - Intraventricular haemorrhage

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Stopping rules for clinical trials

Abstract

Keywords

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