Stopping rules for clinical trials

L. S. Freedman, D. Lowe, P. Macaskill

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


We describe a new method of formulating stopping rules for clinical trials, one that incorporates opinion on what difference is clinically important. We compare the method with conventional group sequential designs and illustrate it by application to a study of Pancuronium Bromide for prevention of haemorrhage in pre‐term infants.

Original languageEnglish
Pages (from-to)167-174
Number of pages8
JournalStatistics in Medicine
Issue number2
StatePublished - 1983
Externally publishedYes


  • Clinical trials
  • Group sequential designs
  • Intraventricular haemorrhage
  • Pre‐term infants
  • Stopping rules


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